ID H5U3D3_9ACTN Unreviewed; 658 AA.
AC H5U3D3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:GAB40241.1};
GN Name=acsA {ECO:0000313|EMBL:GAB40241.1};
GN ORFNames=GOSPT_095_00310 {ECO:0000313|EMBL:GAB40241.1};
OS Gordonia sputi NBRC 100414.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1089453 {ECO:0000313|EMBL:GAB40241.1, ECO:0000313|Proteomes:UP000005845};
RN [1] {ECO:0000313|EMBL:GAB40241.1, ECO:0000313|Proteomes:UP000005845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100414 {ECO:0000313|EMBL:GAB40241.1,
RC ECO:0000313|Proteomes:UP000005845};
RA Yoshida I., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Gordonia sputi NBRC 100414.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB40241.1}.
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DR EMBL; BAFC01000093; GAB40241.1; -; Genomic_DNA.
DR AlphaFoldDB; H5U3D3; -.
DR eggNOG; COG0365; Bacteria.
DR Proteomes; UP000005845; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 19..77
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 91..466
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 542..617
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 658 AA; 70147 MW; 7C55DAF3C859DF43 CRC64;
MDDFAREVAE RHGVDTSSYA TLWAWSVDSP AQFWRAVWDF FDLDAVAGPL AEGAAAVLAS
TDMPGAQWFP DVTLNYVDQV FRHADDPDAA ARTAIVGVDE SGTRVSLTWA QLREQSLAFA
RTLRGLGVGV GDVVAAYLPD IPEALVAFLG TAAVGAIWSG CGQDYAPSGA AGRLAQLEPK
VLVTADGYRY NGKDIDKTAD SAELAGLLEG LGSHIVVGDP SRQPARGIEI LSYESAIASN
SQAQSDVPDA DIPVRVGFDH PLWVLFSSGT TGRPKGIVHG HGGVVVEHLK AAGLHADLSR
DDVFFWHTAL SWMMWNFRAA GLLVGAEIVC YSGSPLYPDA DRLWALVADE GVTYFGTSPG
QLQASRKAGL QPGRDHDLAA LRGIGSTGSA LSADLFDWID ENVRPGIPVS SISGGTDVVT
AFAGGSSGQP VVPGELSVRY LGVALASWAP DTTPLIGEVG EMVVTAPMPS MPVGFWNDPD
GARYRAAYFA HEWSGTDSDS EPVWRHGDWV TVTDRGSLII HGRSDATLNK QGVRMGSADI
YEVVESLPEV AEAFVLGVDG PDGKYWMPLF VTLMPGATLD DDLRSMIASS IRTRLSPRHV
PDEAIEAPGI PHTRTGKKLE VPVTAILAGR TGVDVDPRSI DDPGLIDWYA ARGREHQW
//
