ID H5UXB5_ATLHE Unreviewed; 417 AA.
AC H5UXB5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Multidrug resistance protein MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
DE AltName: Full=Multidrug transporter MdtA {ECO:0000256|HAMAP-Rule:MF_01422};
GN Name=mdtA {ECO:0000256|HAMAP-Rule:MF_01422,
GN ECO:0000313|EMBL:GAB50546.1};
GN ORFNames=EH105704_01_05560 {ECO:0000313|EMBL:GAB50546.1};
OS Atlantibacter hermannii NBRC 105704.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Atlantibacter.
OX NCBI_TaxID=1115512 {ECO:0000313|EMBL:GAB50546.1, ECO:0000313|Proteomes:UP000010297};
RN [1] {ECO:0000313|EMBL:GAB50546.1, ECO:0000313|Proteomes:UP000010297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 105704 {ECO:0000313|EMBL:GAB50546.1,
RC ECO:0000313|Proteomes:UP000010297};
RA Yoshida I., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Escherichia hermannii NBRC 105704.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. {ECO:0000256|HAMAP-Rule:MF_01422}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_01422}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_01422}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|HAMAP-
CC Rule:MF_01422}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB50546.1}.
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DR EMBL; BAFF01000001; GAB50546.1; -; Genomic_DNA.
DR RefSeq; WP_002463191.1; NZ_BAFF01000001.1.
DR AlphaFoldDB; H5UXB5; -.
DR eggNOG; COG0845; Bacteria.
DR Proteomes; UP000010297; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR HAMAP; MF_01422; MdtA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022824; Multidrug-R_MdtA.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01422};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01422}; Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01422};
KW Reference proteome {ECO:0000313|Proteomes:UP000010297};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01422}.
FT TRANSMEM 9..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..133
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT REGION 34..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..152
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 417 AA; 44377 MW; B22B8D6C3457C4AB CRC64;
MKGTGFSRWL MPLVVVIAVV AALWYWHAQK PDAAAGQQAT DQPRKAGGGR TGMRAPLAPV
QAATAVREAV PRYLSGLGTV TAANTVTVRS RVDGQLMALH FQEGQQVKAG DLLAEIDPSQ
FKVALAQAEG QLAKDKATLA NARRDLARYQ QLSKTNLVSR QELDAQQALV NETLGTIKAD
EAAVASAQLQ LNWSRITAPT EGRVGLKQVD IGNQISSGDT AGIVVLTQTH PIDVLFTLPE
SDIATILQAQ KAGKTLTVEA WDRTNKQKLS SGTLLSLDNQ IDVTTGTIKL KARFDNQDDA
LFPNQFVNAR MLVDTQQDAI VIPAAALQMG NDGHFVWVLN GDNQVSKHTV TTGIQDSEKV
VIAAGLSAGD RVVTDGIDRL TEGAKVEVVD AHNAGGNAQQ ADPAQPRGQR PTPGARS
//
