ID H5V804_ATLHE Unreviewed; 569 AA.
AC H5V804;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:GAB54112.1};
GN ORFNames=EH105704_30_00050 {ECO:0000313|EMBL:GAB54112.1};
OS Atlantibacter hermannii NBRC 105704.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Atlantibacter.
OX NCBI_TaxID=1115512 {ECO:0000313|EMBL:GAB54112.1, ECO:0000313|Proteomes:UP000010297};
RN [1] {ECO:0000313|EMBL:GAB54112.1, ECO:0000313|Proteomes:UP000010297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 105704 {ECO:0000313|EMBL:GAB54112.1,
RC ECO:0000313|Proteomes:UP000010297};
RA Yoshida I., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Escherichia hermannii NBRC 105704.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB54112.1}.
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DR EMBL; BAFF01000030; GAB54112.1; -; Genomic_DNA.
DR RefSeq; WP_002438826.1; NZ_BAFF01000030.1.
DR AlphaFoldDB; H5V804; -.
DR eggNOG; COG0286; Bacteria.
DR Proteomes; UP000010297; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000010297}.
FT DOMAIN 12..183
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 202..529
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 569 AA; 64813 MW; D227196BEEB55B9A CRC64;
MNNAEQQFLN ELDNKFWKAA DKLRANMDAA NYKHVVLGLI FLKYVSDAFE ARQQELMTLF
RDVGNPDNIY AMSRDDYSSD EEYAQALLDE LEVEDYYTEK NVFWVPKAAR WETLKNKAML
PTGTVLWVDE TTGKDVILRS VSWLVDNALD EIEKTNPKLK GILNRISQYQ LGNEVLTGLI
NTFSDANFSN PEYKGEKLNL KSKDILGHVY EYFLGQFALA EGKQGGQYYT PKSIVTLIVE
MLQPYNGRVY DPAMGSGGFF VSSDRFIEEH AGEKHYNAAE QKQKISVYGQ ESNPTTWRLA
AMNMAIRGID FNFGNKNADT LLDDQHPDLR ADFVMANPPF NMKEWWHAKL ENDVRWKYGT
PPQGNANFAW MQHMIHHLAP KGSMALLLAN GSMSSNTNNE GEIRRNLIEA DLVECMVALP
GQLFTNTQIP ACIWFLTKDK TGGNGKTHRK GEVLFIDARQ IGYMKDRVLR DFSREDIAKI
ADTFHAWQTD KDYEDEAGFC FSATREDIQK HNFVLTPGRY VGAAEQDEDD EPFAEKMARL
TAQLKDQLEE SAKLEAQIKA NLGGLGYEF
//
