ID H5WH77_EXODN Unreviewed; 180 AA.
AC H5WH77;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430};
DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430};
GN ORFNames=HMPREF1120_11013 {ECO:0000313|EMBL:EHY51771.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OG Mitochondrion {ECO:0000313|EMBL:EHY51771.1}.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY51771.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY51771.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY51771.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC NADH through the respiratory chain, using ubiquinone as an electron
CC acceptor. Essential for the catalytic activity and assembly of complex
CC I. {ECO:0000256|RuleBase:RU004430}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC Evidence={ECO:0000256|RuleBase:RU004430};
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU004430}.
CC -!- SIMILARITY: Belongs to the complex I subunit 6 family.
CC {ECO:0000256|RuleBase:RU004430}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001238; EHY51771.1; -; Genomic_DNA.
DR RefSeq; XP_009161810.1; NW_008751656.1.
DR AlphaFoldDB; H5WH77; -.
DR STRING; 858893.H5WH77; -.
DR GeneID; 20313968; -.
DR VEuPathDB; FungiDB:HMPREF1120_11013; -.
DR HOGENOM; CLU_085957_1_0_1; -.
DR InParanoid; H5WH77; -.
DR OrthoDB; 2328023at2759; -.
DR Proteomes; UP000007304; Mitochondrion.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1.
DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6.
DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ.
DR PANTHER; PTHR33269; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR PANTHER; PTHR33269:SF17; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1.
DR Pfam; PF00499; Oxidored_q3; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|RuleBase:RU004430};
KW Membrane {ECO:0000256|RuleBase:RU004430};
KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:EHY51771.1};
KW NAD {ECO:0000256|RuleBase:RU004430};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Respiratory chain {ECO:0000256|RuleBase:RU004430};
KW Translocase {ECO:0000256|RuleBase:RU004430};
KW Transmembrane {ECO:0000256|RuleBase:RU004430};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004430};
KW Transport {ECO:0000256|RuleBase:RU004430};
KW Ubiquinone {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:EHY51771.1}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 93..111
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
FT TRANSMEM 153..176
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004430"
SQ SEQUENCE 180 AA; 20230 MW; 4B4BA7883FBBF729 CRC64;
MFNGFSVVFL DFFIILSILA GIFTIISKNP IVSVLHLIML FSCISCYLIF LGIKFIGLSY
LLVYVGAVSI LFLFILMLIN IRVSELISNT NNNIPLAILA ILALFIPYNN LTTDTKTNFY
PVDIFFVSSN NWDSNLVDIT DITSIGNVMY TNYSIWLLIT SIILLLAMVG SIVITIKQKY
//