ID H5WIS2_9BURK Unreviewed; 664 AA.
AC H5WIS2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=C-type cytochrome biogenesis protein CcmF {ECO:0000313|EMBL:EHR72978.1};
GN ORFNames=BurJ1DRAFT_4179 {ECO:0000313|EMBL:EHR72978.1};
OS Burkholderiales bacterium JOSHI_001.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=864051 {ECO:0000313|EMBL:EHR72978.1, ECO:0000313|Proteomes:UP000004674};
RN [1] {ECO:0000313|EMBL:EHR72978.1, ECO:0000313|Proteomes:UP000004674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JOSHI_001 {ECO:0000313|EMBL:EHR72978.1,
RC ECO:0000313|Proteomes:UP000004674};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Zeytun A., Lu M., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Smith J., Lewis G.,
RA Woyke T.;
RT "Noncontiguous Finished sequence of Burkholderiales bacterium JOSHI_001.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the biogenesis of c-type cytochromes. Possible
CC subunit of a heme lyase. {ECO:0000256|ARBA:ARBA00037230}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000256|ARBA:ARBA00009186}.
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DR EMBL; CM001438; EHR72978.1; -; Genomic_DNA.
DR AlphaFoldDB; H5WIS2; -.
DR STRING; 864051.BurJ1DRAFT_4179; -.
DR eggNOG; COG1138; Bacteria.
DR HOGENOM; CLU_015041_3_0_4; -.
DR OrthoDB; 9761451at2; -.
DR BioCyc; BBAC864051:G1H30-4163-MONOMER; -.
DR Proteomes; UP000004674; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW.
DR InterPro; IPR032523; CcmF_C.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003567; Cyt_c_biogenesis.
DR InterPro; IPR003568; Cyt_c_biogenesis_CcmF.
DR NCBIfam; TIGR00353; nrfE; 1.
DR PANTHER; PTHR43653; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1.
DR PANTHER; PTHR43653:SF1; CYTOCHROME C-TYPE BIOGENESIS PROTEIN CCMF; 1.
DR Pfam; PF16327; CcmF_C; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01410; CCBIOGENESIS.
DR PRINTS; PR01411; CCMFBIOGNSIS.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytochrome c-type biogenesis {ECO:0000256|ARBA:ARBA00022748};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004674};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..295
FT /note="Cytochrome c assembly protein"
FT /evidence="ECO:0000259|Pfam:PF01578"
FT DOMAIN 315..637
FT /note="Cytochrome c-type biogenesis protein CcmF C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16327"
SQ SEQUENCE 664 AA; 70678 MW; E41B4B0923DB4377 CRC64;
MIAELGHVCL AIALVLSLLQ GVMGLTGASR GTSKLMQASG SAAQGQAVFV ALAFAALAWL
HAQNDFSVLV VSQHSNSQLP LVYRVAAVWG GHEGSMLLWV LMLNGWTGAV TLFSRRLPLE
IVSRVVGVLG LVAAGFHAFL LFTSNPFARL LPAAVDGRDL NPLLQDPGMA IHPPLLYMGY
VGFSVAFAFA IAALLSGRLD AAWARWSRPW TTVAWGFLTL GIAIGSWWAY YELGWGGWWF
WDPVENASFM PWLVGTALIH SLAVTEKRGS FKSWTVLLAI FAFSLSLLGT FLVRSGVLTS
VHAFAVDPKR GIFILGFLVV VVGASLTLFA WRAPKVGLGG GFDTVSRESL LLANNLLFSV
ACAAVLLGTM YPLVLDALGL GKISVGPPYF EAVFAPLMAP AVFLMGLGPL ARWKSASLPE
LSRRVAWAAG VGVAAAVATP IVTGHLSLWT SLAMLLAAWV VATSVVALLQ ATQNANGRRL
AALAAQPRHW WGMWLAHLGV AVFIVGVAGV KSFEQEKTVR MKPGSSATLG SYTFHFDRLG
EVQGPNYRAL KAQISVREGD RMVTVMEPEK RLYNSSGMPM TEAAIMARLS GDLYVSLGDS
VGDDAFGVKL QIKPLVSWIW GGCVVMALGG LLAASDRRYR LRERAARGAP AGGAPALGPV
AEAA
//
