ID   H5WM54_9BURK            Unreviewed;       451 AA.
AC   H5WM54;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Putative exonuclease of the beta-lactamase fold involved in RNA processing {ECO:0000313|EMBL:EHR71939.1};
GN   ORFNames=BurJ1DRAFT_3124 {ECO:0000313|EMBL:EHR71939.1};
OS   Burkholderiales bacterium JOSHI_001.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=864051 {ECO:0000313|EMBL:EHR71939.1, ECO:0000313|Proteomes:UP000004674};
RN   [1] {ECO:0000313|EMBL:EHR71939.1, ECO:0000313|Proteomes:UP000004674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JOSHI_001 {ECO:0000313|EMBL:EHR71939.1,
RC   ECO:0000313|Proteomes:UP000004674};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Zeytun A., Lu M., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Smith J., Lewis G.,
RA   Woyke T.;
RT   "Noncontiguous Finished sequence of Burkholderiales bacterium JOSHI_001.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CM001438; EHR71939.1; -; Genomic_DNA.
DR   AlphaFoldDB; H5WM54; -.
DR   STRING; 864051.BurJ1DRAFT_3124; -.
DR   eggNOG; COG1236; Bacteria.
DR   HOGENOM; CLU_009673_5_2_4; -.
DR   OrthoDB; 9803916at2; -.
DR   BioCyc; BBAC864051:G1H30-3116-MONOMER; -.
DR   Proteomes; UP000004674; Chromosome.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd16295; TTHA0252-CPSF-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Exonuclease {ECO:0000313|EMBL:EHR71939.1};
KW   Hydrolase {ECO:0000313|EMBL:EHR71939.1};
KW   Nuclease {ECO:0000313|EMBL:EHR71939.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004674}.
FT   DOMAIN          13..234
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          246..366
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
SQ   SEQUENCE   451 AA;  49337 MW;  EC62A43A8961C288 CRC64;
     MDIRFLGGAD TVTGSRHLVH IGGQRILLDC GMFQGFKVLR ERNWDTHDLH PDDVDAVVLS
     HAHLDHSGWL PVLVARGYRG PIFASPATCD LAEVLLRDSA HLQEEDARRA NRYGYSRHEK
     ALPLYTSADA RRALSKLQSL PFDRQATIGE VAVALTPVGH LLGASAVTLT HRKEQLVFSG
     DLGRQNDLLM PAPQTVPRAD VLLVESTYGN RRHPHEDGAQ RLAGTIRDTV HRGGSVLLPA
     FAVGRAQALL VVLQRLKRSG AIPADLPVFL DSPMAIQATE LYRHHQKLLR IPAAEARGMA
     DGVRLVSTAQ QSARLARSRY PAVIISASGM ATGGRVLHHL KALLPDERHH IVFAGFQVGG
     SRGANLVAGA REVKIHGEFV PVRAEVSHLE GLSGHADADE LMAWLRALRQ PPRQTFVVHG
     EPEASDALRR RIQDELGWAV RVPQHGQTVQ V
//