ID H5WUI0_9BURK Unreviewed; 793 AA.
AC H5WUI0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EHR69406.1};
GN ORFNames=BurJ1DRAFT_0523 {ECO:0000313|EMBL:EHR69406.1};
OS Burkholderiales bacterium JOSHI_001.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=864051 {ECO:0000313|EMBL:EHR69406.1, ECO:0000313|Proteomes:UP000004674};
RN [1] {ECO:0000313|EMBL:EHR69406.1, ECO:0000313|Proteomes:UP000004674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JOSHI_001 {ECO:0000313|EMBL:EHR69406.1,
RC ECO:0000313|Proteomes:UP000004674};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Zeytun A., Lu M., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Smith J., Lewis G.,
RA Woyke T.;
RT "Noncontiguous Finished sequence of Burkholderiales bacterium JOSHI_001.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; CM001438; EHR69406.1; -; Genomic_DNA.
DR AlphaFoldDB; H5WUI0; -.
DR STRING; 864051.BurJ1DRAFT_0523; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_4; -.
DR OrthoDB; 5287258at2; -.
DR BioCyc; BBAC864051:G1H30-514-MONOMER; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000004674; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000004674}.
FT DOMAIN 8..190
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 194..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 793 AA; 84971 MW; 101B147922BA85CA CRC64;
MNRFQVRKVA VLGAGVMGAQ IAAHLVNVKV PVVLFDLPAK EGPKNGIVSK AVENLKKIKP
APLGVVEDAS LIQQANYEEH LDLLAGCDLV IEAIAERMDW KLDLYTKIAP HLAPGAIVAS
NTSGLSITKL ASVLPDSIKP RFCGIHFFNP PRYMALVELI NTPTTDASVL DELEAFVTTF
LGKSVVRAKD SPNFIANRVG IAGMLATMKE AETFGLTFDV VDDLTGKKLG RASSGTFRTA
DVVGLDTMAH VIKTLQDNLA DDPFYPAYAT PAVLQGLIAA GALGQKTGAG FFKKVGKDIL
RLDPAKKDYV PAGGKADPIV ERMLKKPAAE RLKLLRESSN PQAQFLWAIL RDAFHYAAVH
LEAIADTARD VDFAMRWGFG SKQGPFELWQ EAGWQQVANW VKEDIAAGKA LCAAPLPAWV
FDGRAGVHTP EGSWSPTKKA YVAKSSLPVY ARQPFGENVF GAGAVDPLKS GTEEFRNDDV
RVWTNDGQVL IASITCKLHL ISPAVVEGLL RAVEIAEAKY QGLVIWSPDD VFSAGANLEA
AMPIFMKEGG QGVAKVVKAL QDAMLRMRYA NVPVVAAMRG IALGGGNEIA LHCARRVAHM
ETYVGLVEVG VGLVPAGGGL AYIARRAAEN AATAPGTDLL NFIKDGFMAA ATAKVGTSAI
ESRKNGWLLH SDIIVAHKDE LLHVATAQVK ALAESGYRPP ARSVIPAAGR SALATIKGQM
VNMRDGGFIS QHDFHIGSLI AEVVCGGDVD PGCLVTEEYL MTLERKHFCA LLDNPKTQER
IMGMLQTGKP VRN
//