ID H5XBU1_9PSEU Unreviewed; 625 AA.
AC H5XBU1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Acyl-CoA synthetase/AMP-acid ligase {ECO:0000313|EMBL:EHR52728.1};
GN ORFNames=SacmaDRAFT_4545 {ECO:0000313|EMBL:EHR52728.1};
OS Saccharomonospora marina XMU15.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882083 {ECO:0000313|EMBL:EHR52728.1, ECO:0000313|Proteomes:UP000004926};
RN [1] {ECO:0000313|EMBL:EHR52728.1, ECO:0000313|Proteomes:UP000004926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XMU15 {ECO:0000313|EMBL:EHR52728.1,
RC ECO:0000313|Proteomes:UP000004926};
RX PubMed=22768369; DOI=10.4056/sigs.2655905;
RA Klenk H.P., Lu M., Lucas S., Lapidus A., Copeland A., Pitluck S.,
RA Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G., Land M.,
RA Ivanova N., Rohde M., Goker M., Detter J.C., Li W.J., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the ocean sediment bacterium Saccharomonospora marina
RT type strain (XMU15(T)).";
RL Stand. Genomic Sci. 6:265-275(2012).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CM001439; EHR52728.1; -; Genomic_DNA.
DR RefSeq; WP_009156106.1; NZ_CM001439.1.
DR AlphaFoldDB; H5XBU1; -.
DR STRING; 882083.SacmaDRAFT_4545; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_5_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000004926; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EHR52728.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004926}.
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 61..445
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 510..588
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 625 AA; 67914 MW; F28CAC70637E08A3 CRC64;
MGAYAEQYRY SLSDPEGFWL RAAEAIDWTR APRRALDAST APLYRWFPDA ELNTAYNALD
RHVERGRGEQ AALIWDSPVT GSRRRYSYAE LLDEVARFAG ALASLGVGRG DRVIIYMPMV
PEAVIAMLGC ARIGAVHSVV FGGFAPKELA ARVEDAKPKA IVAASCGIEP TRTVEYKPII
EEALKTTEHQ PDRVVVLQRD AARAELTDRD VDWQQLMAAA SPADPVPVAA TDPLYILYTS
GTTGKPKGVV RDTGGHAVAL AWSMGAVYDI GPGDVWWTAS DVGWVVGHSY IVYAPLLVGA
TSILYEGKPV GTPDAGAFWR VIAEHGAKAL FTAPTALRAI KRVDPDGSEL AKYDLSRFGT
LFMAGERLDP ETYHWAHDKL GVPVIDHWWQ TETGWPIAAN PRGIEKLPVK PGSATVAVPG
WDVRILGQSG EELPPGQEGA IAIRLPLPPG ALPTLWGDDE RFVEAYLSRY EGHYLTGDSG
YRDDDGYLFV MGRTDDVINV AGHRLSTGSI EAVLAGHPAV AECAVIGVHD QLKGQLPWGF
VVLKSGVDID EQRLRDELVA AVRADIGPVA AFRDVSVVDA LPKTRSGKIL RKTMRGIADG
REEPVPSTIE DPDVLDSLRP ILRRQ
//
