ID H6BKQ5_EXODN Unreviewed; 457 AA.
AC H6BKQ5;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Probable kinetochore protein NUF2 {ECO:0000256|ARBA:ARBA00017594};
GN ORFNames=HMPREF1120_00898 {ECO:0000313|EMBL:EHY52689.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY52689.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY52689.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY52689.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|ARBA:ARBA00002772}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NUF2 family.
CC {ECO:0000256|ARBA:ARBA00005498}.
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DR EMBL; JH226130; EHY52689.1; -; Genomic_DNA.
DR RefSeq; XP_009153150.1; XM_009154902.1.
DR AlphaFoldDB; H6BKQ5; -.
DR STRING; 858893.H6BKQ5; -.
DR GeneID; 20305537; -.
DR VEuPathDB; FungiDB:HMPREF1120_00898; -.
DR eggNOG; KOG4438; Eukaryota.
DR HOGENOM; CLU_025461_2_1_1; -.
DR InParanoid; H6BKQ5; -.
DR OMA; YLKMEAH; -.
DR OrthoDB; 7316at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; Ncd80 complex, Nuf2 subunit; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR PANTHER; PTHR21650:SF2; KINETOCHORE PROTEIN NUF2; 1.
DR PANTHER; PTHR21650; MEMBRALIN/KINETOCHORE PROTEIN NUF2; 1.
DR Pfam; PF03800; Nuf2; 1.
DR Pfam; PF18595; Nuf2_DHR10-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT DOMAIN 24..163
FT /note="Kinetochore protein Nuf2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03800"
FT DOMAIN 275..391
FT /note="Nuf2 DHR10-like"
FT /evidence="ECO:0000259|Pfam:PF18595"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 162..291
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 457 AA; 53843 MW; 9FF488D751B57AFB CRC64;
MSQQYRSSQQ QQGRVKKKEE DPADFMRLSE REIASCISEM GIPFQPSDLL KPNPQVIQMV
FEHLGELVMN ATRQSLDPAM RAAAEDVCAE FPELIPVETR LLMGFFIQLR TMLEQCGIND
FSFNDLVRPT HDRLVKIFSY TINFVRFRET HTSVIDENFN KAESTKARIE TLYTENQDME
QRLEEMKHNR KAMEVAVKEK MRRNDELKAR LLELRKGQER VAEQLERAKA EKARAQATLE
EKTERLVKAR QESEKLRPYV LQSPAALQNA LTELSDNLMR DKSQIDLLER RGRALQTSGD
SFTVVQNDVQ ACVKVLEEIA VELQKEEEED ARAAKNRDAL AERGNNVREV EQNEKLLQRQ
LKKWEERTEE MRRKHRERDE ANKAKMDELR EIQRQLRDER AEKGREMERR RVRIEQTEKK
MADLKDNIEN EVHSAHEEYL KLESHIKLYI TEMEQSI
//
