ID H6BPG4_EXODN Unreviewed; 371 AA.
AC H6BPG4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:EHY54423.1};
GN ORFNames=HMPREF1120_02592 {ECO:0000313|EMBL:EHY54423.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY54423.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY54423.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY54423.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
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DR EMBL; JH226131; EHY54423.1; -; Genomic_DNA.
DR RefSeq; XP_009154884.1; XM_009156636.1.
DR AlphaFoldDB; H6BPG4; -.
DR STRING; 858893.H6BPG4; -.
DR GeneID; 20307231; -.
DR VEuPathDB; FungiDB:HMPREF1120_02592; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_026673_16_5_1; -.
DR InParanoid; H6BPG4; -.
DR OMA; YEVIATC; -.
DR OrthoDB; 2688376at2759; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR CDD; cd08249; enoyl_reductase_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR45348:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT DOMAIN 14..308
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 371 AA; 39727 MW; 4513BAEAC76E8261 CRC64;
MHPSNKAAYL IGPKQRPLEV RSAPYTHPQA DEIVIKNHAV AINPLDHIKQ DIGNLLYSWV
KYPAILGTDV AGEVVEVGPN VTHFQVGDRV VGNSIGLAEK HNLASHCGFQ EYTVLLTKMA
SHIPDWLAYE QAAVIPLGLS TAACAMFQKD QLALQYPTVS ASKNSTGKTL LIWGGSTSVG
SNAIQLAVAA GYEVITTASP RNFEYVKKLG AAQVFDYNSS TVVADIKQSF QGKTTAGALS
VGRGAAEMCL SILSSCKGDK FLSMATYPMP PSPPKRLVTL QTAFYYISGI VSLSARARLG
GVRTKFIFGD TLVDNEVGPM IYEDFLPRAL AEKTFVAAPD AEVVGHGLET IQHALDVHKG
GVSARKIVVT L
//
