ID   H6BTZ5_EXODN            Unreviewed;      1292 AA.
AC   H6BTZ5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1120_03704 {ECO:0000313|EMBL:EHY55572.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY55572.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY55572.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY55572.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH226132; EHY55572.1; -; Genomic_DNA.
DR   RefSeq; XP_009156033.1; XM_009157785.1.
DR   GeneID; 20308343; -.
DR   VEuPathDB; FungiDB:HMPREF1120_03704; -.
DR   eggNOG; KOG2029; Eukaryota.
DR   HOGENOM; CLU_001668_1_1_1; -.
DR   InParanoid; H6BTZ5; -.
DR   OMA; CIPDARN; -.
DR   OrthoDB; 2626670at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR48187; LD21810P; 1.
DR   PANTHER; PTHR48187:SF2; LD21810P; 1.
DR   Pfam; PF12697; Abhydrolase_6; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT   DOMAIN          26..157
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF12697"
FT   DOMAIN          381..593
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   REGION          697..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          930..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1193..1228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1259..1292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..724
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        948..994
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1017..1049
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1193..1212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1292 AA;  142952 MW;  BC3266A4A3354C17 CRC64;
     MSTAGKQVVQ YGLTELYAAE EPLVDIVFVH GLNGHPRDTW STSKPEVFWP ADLLPAALRD
     QRPRILTYGY DATVAAFTDG VSKDKIHDHA EHLASRLVAN RALKKAQERP IIFVCHSLGG
     LVVKRCLIYC QSVRHHQHTE RLRSIYVSTY GILFLGTPHN GSNLAKWGSL LQKICAVAFP
     KKFLDSSPQL VHALQANNET LQNINRLFIE VIGRFHVSFF YESKPTDLKG TREFVVEEDS
     AAPLIQGVER MGIEKDHSHM CKFEDESSPG YDVVAATIQR YASDAPALIE SRWVEEKQIA
     DLQRQAAARE LLGDSIFQMS AGASGAVTPT GVSQGDTKSI SINESTGSIR VTEQPLSSSS
     GLLLVAPVGF RPNSVFYGFE TEFEQLGQKL RNDKRRALGT CAALLWGPPG CGKTQIAREY
     LWRHRNDYPA GSFWVDCKTR ESRSKSFWEI GQAVAILGVD QPRDPAWDES SKFVDAVRRW
     FESREGWLIV FDGVAADDDD EIQAFVPFIP DRSGNNIIYT SVDQTLAKRQ RLLNPAGIKV
     SPLSQKEACD LLFKSLGIKE PSALQARKAA EVVNHYECLP LAIHAAAHAL VARGVSLEKF
     KPGTSVHRLA EPFLEILSAL RDHAHPEAVN LVTLLSFFAH TVPVALIRFG QHALLEAGME
     TRSVERVGSM KKEMDNTIAV LRRYGLVERT LLEYAVPSPN RSHSPEENRS QRSVTASSIE
     RPTTELEQHP TDDFNAMLES HITNQSEQSS MESVTYSIDI LRIHSVVQEV VRDELKLRCS
     DQPEHYWWWL TVATNLLCQS YAVADAKIKN SKGRGLVRDY RDYETQATRI WSHFPKSASD
     APPFLRKARH MLHETIRSIR KEIQNESPSQ SFDSLKHRVQ ASIFERASST SSDSPDGESG
     MTRTSTWTLE QMDSHTESPT QIHRVMEFDD SASEGSWTER WSDAGGGSSG ALNASGYHSR
     RPSDAATQEA ATTEASFIQP RRSSILQAIF QGRSMPSTKH KDLGEWKPMP APPTLSHGQA
     QVRSRTSSFT SGSDEFASRP RSTGSEASAS LAAVHRASPP PARGGRIKTP SRPQSMDRTS
     PDGERQPLAL RSPNQRMSPL ATEFEPGVIL PAFETTETPR KHTRHVSSSP RLVQAALNNQ
     TARTMATALP IEENISITRR ISVADPSVLA QSLPVSPHAI VEERLQPSRI IPLGYTSQPM
     SRDTSRESNA SLATAPPAVP GSASLSTSPQ IREPYLYSRP GPASIDLVAA NAWEQGIRVE
     DAEEPANSSL EFDGEDGFGP PQPRFRSGDN TI
//