ID H6BUM4_EXODN Unreviewed; 615 AA.
AC H6BUM4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00019988};
DE EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
DE AltName: Full=Glucosylceramide synthase {ECO:0000256|ARBA:ARBA00031543};
DE AltName: Full=UDP-glucose ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00032575};
DE AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase {ECO:0000256|ARBA:ARBA00031017};
GN ORFNames=HMPREF1120_03059 {ECO:0000313|EMBL:EHY54899.1};
OS Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS yeast) (Wangiella dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY54899.1, ECO:0000313|Proteomes:UP000007304};
RN [1] {ECO:0000313|EMBL:EHY54899.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY54899.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; JH226132; EHY54899.1; -; Genomic_DNA.
DR RefSeq; XP_009155360.1; XM_009157112.1.
DR AlphaFoldDB; H6BUM4; -.
DR STRING; 858893.H6BUM4; -.
DR GeneID; 20307698; -.
DR VEuPathDB; FungiDB:HMPREF1120_03059; -.
DR eggNOG; KOG2547; Eukaryota.
DR HOGENOM; CLU_030898_1_0_1; -.
DR InParanoid; H6BUM4; -.
DR OMA; AKMYVAI; -.
DR OrthoDB; 2786173at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000007304; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0043934; P:sporulation; IEA:UniProt.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EHY54899.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 615 AA; 69920 MW; 9FB40FB803A55F1B CRC64;
MSLNESVRNR KALPVTEVAA CRNVKSSRTP HAGVTFFVLR FLIIWISRFP ALALKFVLTI
LPFRYDILMF GEHVAVTCIA WYIFIVCVCA IGEVYLFLYY RRAPQRAAVL SRDNEQIPHV
TVIRPCKGVE PYLYECLQSS LLQNYPADKI MVHFCVASRS DGAYKTIEKV VRDHPNRDAR
IFIEEEDDAT VHPRAHRDLL GPNPKIRNMS RAYREAKGDL VWIIDCNVWV GRGVCGRMVD
KLHGISASGT KGQPYKLVHH LPISVDVDAY SETQKTNTSS YDDASTAASI LEARRSSRPS
DLIRYGGRLE ELFLSSSHAK MYVAINMVAV APCIVGKSNM FRRSHLDYLT VERARREDPG
APTQARTGID YFSYNICEDH LIGDLLWKSK VPPLPGYPPK MRNHGLVLGD LAIQPVAGMT
VVNYVARRVR WLRVRKFTVP VATLVEPGTE SFLCSAYGAF GLTTCSFTQK WFGNTWAWFC
FWWMVSIVLW ASIDWQIYLL LHSGETIESA EARGDDLPEF ARVLKRGQSR RTFKVWLAAW
LGREALAFPI WFWAIWGGVS VIWRDRRFWV GMDMKVHEIP VPRDSLCHGN VLNGSIDRSD
IVNGLVNGTA HNKRD
//
