ID   H6BYZ4_EXODN            Unreviewed;      1369 AA.
AC   H6BYZ4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1120_04921 {ECO:0000313|EMBL:EHY56857.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY56857.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY56857.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY56857.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH226133; EHY56857.1; -; Genomic_DNA.
DR   RefSeq; XP_009157318.1; XM_009159070.1.
DR   STRING; 858893.H6BYZ4; -.
DR   GeneID; 20309560; -.
DR   VEuPathDB; FungiDB:HMPREF1120_04921; -.
DR   eggNOG; ENOG502QQWJ; Eukaryota.
DR   HOGENOM; CLU_003023_0_0_1; -.
DR   InParanoid; H6BYZ4; -.
DR   OMA; VLKSPKW; -.
DR   OrthoDB; 1984726at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   CDD; cd04043; C2_Munc13_fungal; 1.
DR   Gene3D; 1.10.357.50; -; 1.
DR   Gene3D; 1.20.58.1100; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR010439; MUN_dom.
DR   InterPro; IPR014770; Munc13_1.
DR   InterPro; IPR014772; Munc13_dom-2.
DR   PANTHER; PTHR47263; ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1; 1.
DR   PANTHER; PTHR47263:SF1; C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350); 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF06292; MUN; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS51258; MHD1; 1.
DR   PROSITE; PS51259; MHD2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304}.
FT   DOMAIN          697..823
FT                   /note="MHD1"
FT                   /evidence="ECO:0000259|PROSITE:PS51258"
FT   DOMAIN          904..1021
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          1118..1240
FT                   /note="MHD2"
FT                   /evidence="ECO:0000259|PROSITE:PS51259"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1369 AA;  156368 MW;  106A69BD4A0013D3 CRC64;
     MSQSSHRSRA PSRSLNGVRN GGRRSRDSSR TRGKSIDANE AYLYALRVAY LSYLLQPRTT
     RKRHVETRPA VHRSTTSHSF HELMNDFSVV RDSKSTRYPH DFIKELEKRL KGILVGTERR
     PEYHDALVKR IFAIFLNTLS DPAFKKRMEA DRRAEDLVLI FFSNATKELQ KGKPPGDEGV
     KRMVDRHVAL FVRLLSLILK DRDWARDKPE LASRLQTLES KLLKGDDNLA TSQTNGPLTV
     VEEVVPLTYN VKDMPLVQVV GQIFGLTNTM MQSDINKYKP VWTEKAALQD LKTYQQHLNL
     GTSLTLNAND FDTQEAYESW KKSEGPELSQ LMLAIVQSNP ELAKSTPGGN LPQFNSHATP
     TSPVDSQYAE VSRVLSHQSH SSSYVLDLPA DLGSLDLNAA ESPQHTENAA QIYTFIPSDP
     RAMFRFIMLL ALSHDLNDKT NDGGQLLSKK TTELLNEIAL RWRIPKFTRV VLFLDVIREK
     FVEQAIGLEK LDEAFNYVKD PPQEDPKNKR SSFIMCPAVQ DRYNWTIADF ALMGKVLGTL
     HETLLRDLYE AIMTAYADKA DLQRVGAVMA IIDEHVQSDP NFTQNREEFQ NFKNAAIDGL
     AAEAQRIYDE LLDRELPREN EKWEFYHIQQ VAKAVLKLAE RVQKRFRKNP EILGINPLMV
     LLNCTLPAFA EDSKAMVEQI LNTAQRDGFE VAIQDGFDLY KELSEFRRVH MEALPHVPFP
     YKIEHLMADF VWRWIKITEE QVIGWVENAV KQDNFMVRTQ HPGQVPTEDE RHSTSVIDIY
     SSFSQVIDQV SQLNWDDDLT YAKFMTALSK ALGRGIARYC ELLDQMFSRE MDRLTPEQEA
     AATMTRQEKW VQLAKDTWNN KERVEPFQFY PESFVKLNNI SFAIQEWDKL ESEVNVDACA
     EVIKKNTPPA PQRPRKTSNY VFTIKIVEAE DLKACDVNGF SDPYVVLTDE YQKRLFKSRI
     VYRNLNPRWD ESVDITTQGP LNLIATIWDW DAVGDHDYVG RTSLKLDPSH FSDFLPREYW
     LDLDTQGRVM IRVSMEGERD DIQFYFGKAF RNLQRTQRDM TRKITDKLSA YISHCLSRRA
     LRSLLNRGIS ISSVSSYFNR NRASAAMTTA MPTDAEIVNA LKPLFDYFDD NFAIMQQALT
     SDAMKAVMTR IWKEVLVTIE GLLVPPLSDK PSQQKALSQQ ELDVVFKWLQ SLLEFFNAVD
     EDTGEANGVP LNILKNPKYH ELQMLNFFYF EPTESLIRES ERMASATAAN QQLQRTRLSA
     PANLGAVGGG GLLNAGNPAG GRRAKSIMLS RNLGTMRKAK EEKWKAAQAE PNDDMILRIL
     RMRPEAASYL RDRSRQKERL AAAAAAEMIV RQSLLAGGGR MTGPSVVRR
//