ID   H6C4V2_EXODN            Unreviewed;      1276 AA.
AC   H6C4V2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHY58529.1};
GN   ORFNames=HMPREF1120_06539 {ECO:0000313|EMBL:EHY58529.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY58529.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY58529.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY58529.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
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DR   EMBL; JH226134; EHY58529.1; -; Genomic_DNA.
DR   RefSeq; XP_009158990.1; XM_009160742.1.
DR   AlphaFoldDB; H6C4V2; -.
DR   STRING; 858893.H6C4V2; -.
DR   GeneID; 20311178; -.
DR   VEuPathDB; FungiDB:HMPREF1120_06539; -.
DR   eggNOG; KOG2020; Eukaryota.
DR   HOGENOM; CLU_003712_0_0_1; -.
DR   InParanoid; H6C4V2; -.
DR   OMA; IAKRSWG; -.
DR   OrthoDB; 2721902at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045478; Exportin-5_C.
DR   InterPro; IPR045065; XPO1/5.
DR   PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR   PANTHER; PTHR11223:SF3; EXPORTIN-5; 1.
DR   Pfam; PF19273; Exportin-5; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          118..188
FT                   /note="Exportin-1/Importin-beta-like"
FT                   /evidence="ECO:0000259|Pfam:PF08389"
FT   DOMAIN          340..1221
FT                   /note="Exportin-5 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19273"
FT   COILED          476..503
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1276 AA;  143621 MW;  0488C4F5D50196A4 CRC64;
     MTDTFAVNGA SNGADSVSYD TANIIQALQI THNPTTKNDV RFEALRYLEK LKERREALEY
     GFSLSTDLSQ PPVVRHFGLG LLSHVIRHEA YHLSEEQNAQ LRNCVLELGK SIVPSDLSFI
     RNKIAELWIE LAKRSWALDW FDLDEQLVRL WSQELVHKDF VLTVLENLSE DIFVRDDSMA
     VLRGRDLNSA FVEIITSSSN YAGGIKIGDA VHHVRYGSEG WLTRIRQYLE ECANNPDLAG
     AVKDTTIKAL ATLRSVFVWV MTPAVAQSMS LAVTCRFLTN SDPDLVMAAV DALLSLYGRT
     RLEELEVQAL VYPLIQPEGI AGLSQLYSWS IVSVDEIDSS KYVVSKKLSE LMSLLAVHTT
     RYAPPDPNTL DLSPFLHFMI AIAEHESLIV SIPVVHAWVQ LLEVKTWRKA PVVSECIGPL
     LQVASRRLIQ YDQLPEGTDD PVVAFVNDEI ELFPERQGFY LSYRRLCSAV IEWICYAQLE
     EALQAVMNRA DELLDEVQTA EQQLDPASYE RVSMNVLRAD SYFAMVDAAL NGLDRWQAKH
     REGQTAEQEQ LAARVRESAK RWLLNMSKKR EFRDPQIRQR QIKTAVEASN RALQKDTGFA
     FSVLEHILSS FIITPPQHSL YAEAVTELHN YATSELRRLS LQHADYFVTF YDQLESRFTD
     LINQLGGDER IQIDLKSILF SIIQRAGAVD YAQRQAKLEG FLQSVAAAWA DSSLQDTLQS
     LETFARSQAF DRVGPYMASI GAANVEDWSQ VPYNERGVQI QRDMLMAFSK LPLRETRILL
     SISTDRLEQG SALHRMICDL WTPLIPNMLP HVLRLTSYNH QLHNPAAWPN VNTPELQALI
     RRVLRDRYWQ SGISSGSMNE FHSKVKSTRS TIEGFASSVR GRIRNNLEQC YSILHTLGRL
     GPAFYSLQQL PEMMAEAAIN TAAPLSPHHF SVMIQMLPKL IDECPPEHRQ HFLTPILSSL
     LQQMDAKLTE EWVKMDERKQ TKHEEENLND EMRDDSVLRQ TTYKAVNLVA HWLNPKREAQ
     LRTKKSIVNG NYLNDESQQT MRQFVLSNVQ ILERLLVFVT HALAFRDTRS CYTMLGAVQR
     IVPEFGHGHG ERLLSGDEAA AAREYISSEM LKTAITCLND GYFADHQQHY AQLIATIWVS
     YGLPAHASGS ESTTPAGARD LPPLTATPRN VILSLPGMTE EKVDRAAAQL AREGSVARPK
     KLRAIVLSLL EGVRGVRLSE LGKIDLRPQQ SKILEKYKQR ESLGMQGVED GVGGAAANGA
     ADDGIDLGGV ADMFAG
//