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Database: UniProt
Entry: H6C563_EXODN
LinkDB: H6C563_EXODN
Original site: H6C563_EXODN 
ID   H6C563_EXODN            Unreviewed;      1033 AA.
AC   H6C563;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   13-FEB-2019, entry version 38.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=HMPREF1120_07758 {ECO:0000313|EMBL:EHY59775.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656)
OS   (Black yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY59775.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|Proteomes:UP000007304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34100 / CBS 525.76 / NIH/UT8656
RC   {ECO:0000313|Proteomes:UP000007304};
RX   PubMed=24496724; DOI=10.1534/g3.113.009241;
RA   Chen Z., Martinez D.A., Gujja S., Sykes S.M., Zeng Q., Szaniszlo P.J.,
RA   Wang Z., Cuomo C.A.;
RT   "Comparative genomic and transcriptomic analysis of Wangiella
RT   dermatitidis, a major cause of phaeohyphomycosis and a model black
RT   yeast human pathogen.";
RL   G3 (Bethesda) 0:0-0(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; JH226135; EHY59775.1; -; Genomic_DNA.
DR   RefSeq; XP_009160236.1; XM_009161988.1.
DR   EnsemblFungi; EHY59775; EHY59775; HMPREF1120_07758.
DR   GeneID; 20312397; -.
DR   InParanoid; H6C563; -.
DR   OrthoDB; 179316at2759; -.
DR   BioCyc; GCF_000230625-HMP:HMPREF1120_07758-MONOMER; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007304};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1033       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5003602949.
FT   DOMAIN      398    582       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   1033 AA;  112386 MW;  006A2BABD881D971 CRC64;
     MTMRLTLLSA VLAILAVQVT GLVARPRTLG GFSIVEHPDP EKRALLQNIV TWDERSLFIH
     GERIMIFSGE VHPFRLPVPS LWLDVFQKIK ALGFNCVSFY VDWALLEGTP GNYSAEGVFA
     LEPFFEAASS AGIYLLARPG PYINAEVSGG GFPGWLQRLR GTLRTTDADF LAATENYVRH
     VASTIAKAQI TNGGPVILYQ PENEYSGFCC GYTKPDGQYM QDVMDQARQA GIVVPMLSND
     AGVNGYNAPG TGVGAVDIYG HDGYPLGFDC ANPTVWPRGK LPTDWWQKHL NQSPTTPYSV
     TEFQAGSFDP WGGPGFEKCG VLVNSEFERV FYKNDLSFGV KILNLYMTFG GTNWGNLGHP
     GGYTSYDYAA PIDENRQVER EKYSQLKLIA NFVKTSPSYF DAEQLPNSTT MYTTTADLTV
     TPVKSNSSLS TFWAVRHTDY ASQESTSYKL TIPTSAGNLT IPQLGGGVLT LNGRDSKIHV
     SDYDIRGTTL LYSTAEILTW KVFGSRKVVI LYGAEGEHHE VSVLSTAAAS LVEGSDAGVT
     FGTGTGTGSS ATIAWHTSPS RRVVKVGDLE IYILDRNSAY NYWIPELSTN GTSASFGSQE
     ATASSIIVKA GYLVRSASLV DDQLQITADF NATTAIEIIG VPSAAKTLCV NGQSVQYSAD
     ARSGDWSNIT VSWTDPGITL PALNSLDWKY IDSLPEVNDP DYDDSKWVVA DHATTNNTVR
     NLTTPTSLYA SDYGFHTGSL IYRGHFRAAD TNNESNVSLY LNTQGGSAFG HSVWLNQTYL
     GSWAGVSTEN NTNATYNLPQ LDAGKDYVVT VLIDHMGLEE SGTVGADKMK TPRGILNYAL
     LSGSDTLASS DITWKLTGNL GGEHYQDRVR GPLNEGGLYA ERQGFHLPYP PSTTWESASP
     FQGLSGPGVA FYTAQFDLDI PQGWDVPMSF NFGNTTSSTT GGSPAKFRVQ LFVNGFQYGK
     YINHIGPQTS FPVPEGILNY HGTNWLALTL WAHEPSGAKL DSFELVHGTP VLTALRDIAF
     VGQEGWTQRQ DAY
//
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