ID   H6C886_EXODN            Unreviewed;       700 AA.
AC   H6C886;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Vps52/Sac2 family protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1120_08279 {ECO:0000313|EMBL:EHY60313.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY60313.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY60313.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY60313.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the VPS52 family.
CC       {ECO:0000256|ARBA:ARBA00008180}.
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DR   EMBL; JH226136; EHY60313.1; -; Genomic_DNA.
DR   RefSeq; XP_009160774.1; XM_009162526.1.
DR   AlphaFoldDB; H6C886; -.
DR   STRING; 858893.H6C886; -.
DR   GeneID; 20312918; -.
DR   VEuPathDB; FungiDB:HMPREF1120_08279; -.
DR   eggNOG; KOG1961; Eukaryota.
DR   HOGENOM; CLU_010797_1_0_1; -.
DR   InParanoid; H6C886; -.
DR   OMA; IHVVMVE; -.
DR   OrthoDB; 2723231at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007258; Vps52.
DR   InterPro; IPR048361; Vps52_C.
DR   InterPro; IPR048319; Vps52_CC.
DR   PANTHER; PTHR14190; SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52; 1.
DR   PANTHER; PTHR14190:SF7; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG; 1.
DR   Pfam; PF20655; Vps52_C; 1.
DR   Pfam; PF04129; Vps52_CC; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          167..335
FT                   /note="Vps52 coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF04129"
FT   DOMAIN          352..693
FT                   /note="Vps52 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20655"
FT   REGION          1..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..224
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        43..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  77161 MW;  C67E0933C99C8498 CRC64;
     MWLDRLAGGA ASPSGSLTPS RPYSPSPRKG ERSHLAPAQR AGYNLSANKS STSLDLSANS
     STTSLSAPPR PAVNGSSLRF EQRPPPDVPD PLKVLGDILG NRPKQNGADS VTSAGKGTGA
     PGRRKTEVNI DFGGLSLDEF VDQDIPEAAV DNRQSSAIPI PAKENRQKYE DFHNSIAECD
     QVLKTVETYL TNFQAELGQV SAEIENLQAR SVQLNAKLDN RRKVEKLLGP AVEDVTLSPM
     TVRSLAEGAI DETFLKALNE VEARSAMIEA KEDKGEDVKA LQDLKPLLEN LKARAVERIR
     DYIVAQIKAL RAPNINAQII QQQSFLEYKD LYAFLARNHA VLAEEIGQAY VNTMRWYYSS
     HFARYQQSLE KLQLHVYDQH DLLGSEPAPA RRNVQSSKPS TAAAHAANPP HHHQHDAYSL
     GRRDEILRSK NDAALPAYLA EDNSKTSAQA HHIEIPFRNF NRALIDNVCA EYFVVTELFS
     TSTYHQISRR VSEIFEPTFA IGHNLTKHLV EHTNDGLGLL LCVRLNQHFA FELQRRKVPV
     ADSYINLTNI LLWPRFQMVM DLHCESLKKV PAPTAHGYRG AAAAFSLVGG GSGSDPSKAA
     SVAPHAITQR FGQFLHGILM LSAEAGDDEP VSNSLARLRS EYETLMGKLA KGAGGDASKR
     QRFLYNNYSL VLTIISDTKG KLAEEQKEHF GALVRDNKSR
//