ID   H6C9U0_EXODN            Unreviewed;       680 AA.
AC   H6C9U0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=SET domain-containing protein {ECO:0000259|PROSITE:PS50280};
GN   ORFNames=HMPREF1120_07919 {ECO:0000313|EMBL:EHY59943.1};
OS   Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black
OS   yeast) (Wangiella dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=858893 {ECO:0000313|EMBL:EHY59943.1, ECO:0000313|Proteomes:UP000007304};
RN   [1] {ECO:0000313|EMBL:EHY59943.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NIH/UT8656 {ECO:0000313|EMBL:EHY59943.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Wang Z., Hunicke-Smith S., Szanislo P.J., Earl A., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA   Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala (Wangiella) dermatitidis NIH/UT8656.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; JH226136; EHY59943.1; -; Genomic_DNA.
DR   RefSeq; XP_009160404.1; XM_009162156.1.
DR   AlphaFoldDB; H6C9U0; -.
DR   STRING; 858893.H6C9U0; -.
DR   GeneID; 20312558; -.
DR   VEuPathDB; FungiDB:HMPREF1120_07919; -.
DR   eggNOG; ENOG502RA1J; Eukaryota.
DR   HOGENOM; CLU_423889_0_0_1; -.
DR   InParanoid; H6C9U0; -.
DR   OrthoDB; 2101177at2759; -.
DR   Proteomes; UP000007304; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd20071; SET_SMYD; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR   PANTHER; PTHR12197:SF301; SET DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00856; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007304};
KW   Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT   DOMAIN          32..227
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..539
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  77708 MW;  106B6AFCD74C948A CRC64;
     MTRSPSLEGE KRGLHLRPPE PDAEGWRIVS AGDVETGSTL LNLGAVFMDL PDDYARPWPG
     PDEIGKGEFA NIIRKVKRAI NVVMENLPVR ARSLRPEDPF SRLIDYRRRE YAHTGRFSNA
     DVLEALYGKR PRPGVEPSEG QKQDLALVGR WFTDVLEFDH PLFEPPGHPI FVFGRLLCSI
     NHSCRPNVAL TPILGEKDHD SQLHEGTVGI RAIRPIKQGE EIRFSYVATL RETRERQRSV
     LAENFGFDCR CDACNFEQHN ATERDLKDVV YGLYNDVLES ELDGEATTAP PVYRKAVLVL
     DGFDALEINH KPKRDVLDKC GIHAMLATDS LRVHYFLSRA LEWAKATYTD EAHPHIVDTK
     TQIKAFMRED WYDGEDAPRF GCSAYQEYDM NQDNLEELMF MMNHPQNDTV YRPLHVVNGK
     VEEMSMREHR KYLNGLRQPW KQKEQKRADR LRAINDKIKE MEAKDELNSK RVSKKPKNEV
     KSIVQEDEED EEDDEDEEYE QEDEDDEDEE YEQEDEDDEE EEENDEDEDE GEEDDEEVVS
     PPASMPVTLP MTPPVTPSAS LPVPLPFKMP AQRRFVCPFG AKDGTSKQAW LQSAATKAAL
     RLEARDVGHL LAAKDGMGTN QEGFVLNARR DSVAGRIQGE KEFLQLGGRL GRKARTHSFG
     NDGSRRDLLK EAEVRESKCW
//