ID H6L4R0_SAPGL Unreviewed; 323 AA.
AC H6L4R0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=O-methyltransferase family 2 {ECO:0000313|EMBL:AFC23984.1};
DE EC=2.1.1.76 {ECO:0000313|EMBL:AFC23984.1};
GN OrderedLocusNames=SGRA_1249 {ECO:0000313|EMBL:AFC23984.1};
OS Saprospira grandis (strain Lewin).
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Saprospiraceae;
OC Saprospira.
OX NCBI_TaxID=984262 {ECO:0000313|EMBL:AFC23984.1, ECO:0000313|Proteomes:UP000007519};
RN [1] {ECO:0000313|EMBL:AFC23984.1, ECO:0000313|Proteomes:UP000007519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lewin {ECO:0000313|EMBL:AFC23984.1,
RC ECO:0000313|Proteomes:UP000007519};
RX PubMed=22675601; DOI=10.4056/sigs.2445005;
RA Saw J.H., Yuryev A., Kanbe M., Hou S., Young A.G., Aizawa S., Alam M.;
RT "Complete genome sequencing and analysis of Saprospira grandis str. Lewin,
RT a predatory marine bacterium.";
RL Stand. Genomic Sci. 6:84-93(2012).
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DR EMBL; CP002831; AFC23984.1; -; Genomic_DNA.
DR RefSeq; WP_015691629.1; NC_016940.1.
DR AlphaFoldDB; H6L4R0; -.
DR STRING; 984262.SGRA_1249; -.
DR KEGG; sgn:SGRA_1249; -.
DR eggNOG; COG2813; Bacteria.
DR HOGENOM; CLU_005533_12_0_10; -.
DR OrthoDB; 9766840at2; -.
DR Proteomes; UP000007519; Chromosome.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0030755; F:quercetin 3-O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:AFC23984.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007519};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:AFC23984.1}.
FT DOMAIN 9..70
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 105..303
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 235
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 323 AA; 36459 MW; D9D4FCCE1BBD661D CRC64;
MSISQELKNS FTSYWHYLPL RTACQLGVFD ALWEGPLSLA ELAEKLGAKQ ASLQLLLAAL
EQLAALRTEN GQYVLAEKGA QLAEEHPQSL KYACLLWGEE HLRAWQHLAQ SIRSDEAVFE
QLYGQPFFDY LDEQPESNRI YHLAMNEYAR DDYAQLGEQL DLSEAKAVMD LGGGLGALLK
ALARVHPQPK YYLLDKPKVL ALLPAGELPF RPIPADFFAP IPQVAEHIFL ARVLHDWPDE
AALKILENVY AALPKGGRMY ILEILKEQLA DGAELLSLNM LAICKSQERT LAAYRKLAEK
IGFAYLEKRP INDLQTLLIF EKR
//
