ID H6N009_GORPV Unreviewed; 568 AA.
AC H6N009;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Uracil/xanthine permease {ECO:0000313|EMBL:AFA74461.1};
GN OrderedLocusNames=GPOL_c34490 {ECO:0000313|EMBL:AFA74461.1};
OS Gordonia polyisoprenivorans (strain DSM 44266 / VH2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1112204 {ECO:0000313|EMBL:AFA74461.1, ECO:0000313|Proteomes:UP000009154};
RN [1] {ECO:0000313|EMBL:AFA74461.1, ECO:0000313|Proteomes:UP000009154}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44266 / VH2 {ECO:0000313|Proteomes:UP000009154};
RX PubMed=22327575; DOI=10.1128/AEM.07969-11;
RA Hiessl S., Schuldes J., Thurmer A., Halbsguth T., Broker D., Angelov A.,
RA Liebl W., Daniel R., Steinbuchel A.;
RT "Involvement of two latex-clearing proteins during rubber degradation and
RT insights into the subsequent degradation pathway revealed by the genome
RT sequence of Gordonia polyisoprenivorans strain VH2.";
RL Appl. Environ. Microbiol. 78:2874-2887(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP003119; AFA74461.1; -; Genomic_DNA.
DR AlphaFoldDB; H6N009; -.
DR STRING; 1112204.GPOL_c34490; -.
DR KEGG; gpo:GPOL_c34490; -.
DR eggNOG; COG2233; Bacteria.
DR HOGENOM; CLU_017959_8_2_11; -.
DR Proteomes; UP000009154; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009154};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 568 AA; 59731 MW; 04AF91F21F2DDA2F CRC64;
MFMTVLDTIK RGRDADHPVD DIPPLTKLFP LGLQHVMAMY AGAVAVPLIV GGAMVGAGQM
RSDEIVHLIT ADLFVAGIAT LLQAVGFWRF GVRLPLMQGV TFAAVGPMIT IGLNHGITAI
YGSVIACGVF MILVAPIVGR LIRFFPPLVT GTIILIIGVS LMSVAAGWFG GGTNNGEDFG
APKSIAFGFG TLLLIILLER FAPAAIKRVS VLVGLVLGTL ISIPFGMTDW SGVGQSSWIA
VPQPFYFGVP SFDVSSIIAM IIVALVIMTE TTGDIVAVGE IVDKKITPRK LADGMRADGV
GTVLGGIFNT FPYTAFAQNV GLVAITGVKT RHVATCAGAI LVVLGLLPKM AAIIEGIPQP
VLGGAGVALF GMVAASGVRT LTRVKFNNTN ILVVAISVGV AMLSEASLSY TNDNGETVSL
DLYHQFPDWF QTIFHSGISA GAITAILLNL LLNWRSTSPD PVDYHNTGEI EVVDADGLSG
SDAPRYGAFD PRDALAAADP DTDPATLRVL AEHDAGLHRF IVTNPSAPQE LCEWIRAQGD
PKVTALLDRW DDKTGGKFSA RDTGTPAT
//
