ID H6N5Y3_MYCHN Unreviewed; 320 AA.
AC H6N5Y3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=HPr kinase/phosphorylase {ECO:0000313|EMBL:AEW44898.1};
DE EC=2.7.11.- {ECO:0000313|EMBL:AEW44898.1};
GN Name=hpr {ECO:0000313|EMBL:AEW44898.1};
GN OrderedLocusNames=MHC_00160 {ECO:0000313|EMBL:AEW44898.1};
OS Mycoplasma haemocanis (strain Illinois).
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=1111676 {ECO:0000313|EMBL:AEW44898.1, ECO:0000313|Proteomes:UP000009135};
RN [1] {ECO:0000313|EMBL:AEW44898.1, ECO:0000313|Proteomes:UP000009135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Illinois {ECO:0000313|EMBL:AEW44898.1,
RC ECO:0000313|Proteomes:UP000009135};
RX PubMed=22374945; DOI=10.1128/JB.06781-11;
RA do Nascimento N.C., Guimaraes A.M., Santos A.P., Sanmiguel P.J.,
RA Messick J.B.;
RT "Complete genome sequence of Mycoplasma haemocanis strain Illinois.";
RL J. Bacteriol. 194:1605-1606(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-
CC serine + ADP + H(+); Xref=Rhea:RHEA:46600, Rhea:RHEA-COMP:11602,
CC Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001120};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr
CC protein]-L-serine + diphosphate; Xref=Rhea:RHEA:46604, Rhea:RHEA-
CC COMP:11602, Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; Evidence={ECO:0000256|ARBA:ARBA00001319};
CC -!- SIMILARITY: Belongs to the HPrK/P family.
CC {ECO:0000256|ARBA:ARBA00006883}.
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DR EMBL; CP003199; AEW44898.1; -; Genomic_DNA.
DR RefSeq; WP_014271960.1; NC_016638.1.
DR AlphaFoldDB; H6N5Y3; -.
DR STRING; 1111676.MHC_00160; -.
DR KEGG; mhe:MHC_00160; -.
DR HOGENOM; CLU_052030_0_1_14; -.
DR OrthoDB; 9778803at2; -.
DR Proteomes; UP000009135; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd01918; HprK_C; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003755; HPr(Ser)_kin/Pase.
DR InterPro; IPR011104; Hpr_kin/Pase_C.
DR InterPro; IPR011126; Hpr_kin/Pase_Hpr_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR NCBIfam; TIGR00679; hpr-ser; 1.
DR PANTHER; PTHR30305:SF1; HPR KINASE_PHOSPHORYLASE; 1.
DR PANTHER; PTHR30305; UNCHARACTERIZED; 1.
DR Pfam; PF07475; Hpr_kinase_C; 1.
DR Pfam; PF02603; Hpr_kinase_N; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEW44898.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009135};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEW44898.1}.
FT DOMAIN 2..102
FT /note="HPr(Ser) kinase/phosphorylase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02603"
FT DOMAIN 132..301
FT /note="HPr kinase/phosphorylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07475"
SQ SEQUENCE 320 AA; 36411 MW; 23B1D57D4430FFDA CRC64;
MIKVLSIYKR FNGKYLNRTP DNEQREILFP GFNRLGMELN GCFLNEQNRS VVCWGKQESN
FLDLFEENKQ IEILSKILET DPPLFLLSNN FRHSDLLHKL NKDLNGNRSA LICMGYSTLE
IFTLIGTWIA KTFAKWTTVH GVVLNVYGEG VLITGEAGVG KSEAAAELLK MNHLFLGDDA
IDIARIGNTI VAKANPFSEG FMHIRGLGIL NMREMYGGMK MIDETRITMV VNLKDQKDEN
KLHFENVGEE INYRPLLEVP LPYYVIPVTS GRKISEIIEL AVIDMKLKRK GYSAAQEMNR
KYKKLIAANQ KSSNDQTKIQ
//
