ID H6R2P8_NOCCG Unreviewed; 372 AA.
AC H6R2P8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Pyruvate dehydrogenase E1 COMPONENT (ALPHA SUBUNIT) PDHA (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE) {ECO:0000313|EMBL:CCF61898.1};
GN Name=pdhA {ECO:0000313|EMBL:CCF61898.1};
GN OrderedLocusNames=NOCYR_1090 {ECO:0000313|EMBL:CCF61898.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF61898.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF61898.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF61898.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; FO082843; CCF61898.1; -; Genomic_DNA.
DR AlphaFoldDB; H6R2P8; -.
DR STRING; 1127134.NOCYR_1090; -.
DR KEGG; ncy:NOCYR_1090; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_1_0_11; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:CCF61898.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 51..318
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 372 AA; 40796 MW; 9535B4718ABBCC23 CRC64;
MQEAVKEMLG KPSYPVQLIQ PDGRRVLDRE HAAVVADIGP DKLRDLYEDL VVTRRIDTEA
TALQRQGQLG LWAPLLGQEA AQVGSARALH PDDYVFCSYR EAAVAYCRGV DPAQLTRMWR
GVAHSCWDPD VIKTTNPAIV VGAQGLHATG YAYAAHLEGA DIATIAYFGD GATSQGDIAE
ALGFAASWSA PVVFFCQNNH WAISEPVRLQ SATPIAQRAL GYGIPSVQVD GNDVLAVLAV
TRQALARAHA GGGPSFIEAI TYRMGPHTTA DDPTRYRSDA ETEEWKKRDP IDRVHRLLGR
ENLLDEQFEQ RVRDRADEIA SVVRTATITM PDPDPMELFE HVYSTEHPLI AEQRRAYAQH
LAAHASTEGV PS
//
