ID H6R5M0_NOCCG Unreviewed; 439 AA.
AC H6R5M0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Isochorismate synthase/isochorismate-pyruvate lyase mbtI (Salicylate synthase mbtI) (Mycobactin synthetase protein I) {ECO:0000313|EMBL:CCF63351.1};
GN Name=mbtI {ECO:0000313|EMBL:CCF63351.1};
GN OrderedLocusNames=NOCYR_2581 {ECO:0000313|EMBL:CCF63351.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF63351.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF63351.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF63351.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; FO082843; CCF63351.1; -; Genomic_DNA.
DR RefSeq; WP_014350811.1; NC_016887.1.
DR AlphaFoldDB; H6R5M0; -.
DR STRING; 1127134.NOCYR_2581; -.
DR KEGG; ncy:NOCYR_2581; -.
DR eggNOG; COG0147; Bacteria.
DR HOGENOM; CLU_006493_2_1_11; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016833; F:oxo-acid-lyase activity; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR019996; Salicylate_synthase.
DR NCBIfam; TIGR03494; salicyl_syn; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF48; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CCF63351.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyruvate {ECO:0000313|EMBL:CCF63351.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 170..420
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 245..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 46803 MW; 1F82A1AEF5D743F2 CRC64;
MNRPTTLDAD GYVHSTRPHT GDPLALATAI AASSQLTDFA VYEQPGRWYV AGNPVGAITV
GPDRVRSTLG GDHTESWSGT PWPQIRAALA RAPIPGWRAY GWACFELQNP SIAPPGEVLA
YIMVPGVELE ITGDAVHIRS YGAPFDLDLP ENYRPATEPT PMPVDEIDTA YLRRVRAALD
RIGAGEFDKV IMSRRVDLPF AVDMPATYAA VRRANTPARS FLLDLGGWQA AGVSPETVLE
ADGAGLATTQ PLAGTRARTG DPGRDRALRD ELLADPKEIY EHATSVRLAF AELAGVGSAT
RVSEFLTVKE RGSVQHLASR VETLLPADRD GWDALAAVFP AITASGIPKA PACAAIDELE
PGARGLYSGA VLRADSTGNL DAALVLRAVY QRDGRSWLRA GAGVVTGSTP EREHEETREK
LSCVAPYLIA DHSGPATGR
//
