ID H6R7S1_NOCCG Unreviewed; 285 AA.
AC H6R7S1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Sulfate transport system permease protein CysT {ECO:0000256|RuleBase:RU366001};
GN Name=cysU {ECO:0000313|EMBL:CCF62265.1};
GN OrderedLocusNames=NOCYR_1469 {ECO:0000313|EMBL:CCF62265.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF62265.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF62265.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF62265.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- FUNCTION: Part of the ABC transporter complex (TC 3.A.1.6.1) involved
CC in sulfate/thiosulfate import. {ECO:0000256|RuleBase:RU366001}.
CC -!- FUNCTION: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1)
CC involved in sulfate/thiosulfate import. Probably responsible for the
CC translocation of the substrate across the membrane.
CC {ECO:0000256|ARBA:ARBA00025323}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CysA),
CC two transmembrane proteins (CysT and CysW) and a solute-binding protein
CC (CysP). {ECO:0000256|ARBA:ARBA00011779}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000256|RuleBase:RU366001}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366001}.
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DR EMBL; FO082843; CCF62265.1; -; Genomic_DNA.
DR AlphaFoldDB; H6R7S1; -.
DR STRING; 1127134.NOCYR_1469; -.
DR KEGG; ncy:NOCYR_1469; -.
DR eggNOG; COG0555; Bacteria.
DR HOGENOM; CLU_016047_14_0_11; -.
DR OrthoDB; 9774448at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015419; F:ABC-type sulfate transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR InterPro; IPR011865; CysT_permease.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR005667; Sulph_transpt2.
DR NCBIfam; TIGR00969; 3a0106s02; 1.
DR NCBIfam; TIGR02139; permease_CysT; 1.
DR PANTHER; PTHR30406; SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN; 1.
DR PANTHER; PTHR30406:SF8; SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN CYST; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366001};
KW Reference proteome {ECO:0000313|Proteomes:UP000008190};
KW Sulfate transport {ECO:0000256|ARBA:ARBA00023032,
KW ECO:0000256|RuleBase:RU366001};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366001};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366001};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366001}.
FT TRANSMEM 30..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT TRANSMEM 75..101
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366001"
FT DOMAIN 75..269
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50928"
SQ SEQUENCE 285 AA; 30099 MW; AEDE233F3800709C CRC64;
MTDSNNSAAA PARTGPNWSW LRVTGSVGPL GIATAVLWLS VIVLLPLAAL TVNAFDDGWS
GFWDAITAPV ALASLRVTVL VSIVVALINV VMGTLIAWVL VRDDFPGKGI VNALIDLPFA
LPTIVASIVL LSLYGPQSPF NIHLNATQPG LVVALAFVTL PFVVRSVQPV LIELDREVEQ
AALSLGADNF TTFRRIVLPA LAPAIISGGG LAFARAIGEF GSVVLIGGNI PRETQMASQY
IQQQIEVDQP VSAAAVSVAL LAIAFVTLLT LRLFVARMSR KEEES
//
