ID H6RBW3_NOCCG Unreviewed; 287 AA.
AC H6RBW3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Putative 3-alpha,7-alpha, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase {ECO:0000313|EMBL:CCF61306.1};
GN OrderedLocusNames=NOCYR_0489 {ECO:0000313|EMBL:CCF61306.1};
OS Nocardia cyriacigeorgica (strain GUH-2).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1127134 {ECO:0000313|EMBL:CCF61306.1, ECO:0000313|Proteomes:UP000008190};
RN [1] {ECO:0000313|EMBL:CCF61306.1, ECO:0000313|Proteomes:UP000008190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GUH-2 {ECO:0000313|EMBL:CCF61306.1,
RC ECO:0000313|Proteomes:UP000008190};
RX PubMed=22461543; DOI=10.1128/JB.00161-12;
RA Zoropogui A., Pujic P., Normand P., Barbe V., Beaman B., Beaman L.,
RA Boiron P., Colinon C., Deredjian A., Graindorge A., Mangenot S.,
RA Nazaret S., Neto M., Petit S., Roche D., Vallenet D., Rodriguez-Nava V.,
RA Richard Y., Cournoyer B., Blaha D.;
RT "Genome sequence of the human- and animal-pathogenic strain Nocardia
RT cyriacigeorgica GUH-2.";
RL J. Bacteriol. 194:2098-2099(2012).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
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DR EMBL; FO082843; CCF61306.1; -; Genomic_DNA.
DR RefSeq; WP_014348781.1; NC_016887.1.
DR AlphaFoldDB; H6RBW3; -.
DR STRING; 1127134.NOCYR_0489; -.
DR KEGG; ncy:NOCYR_0489; -.
DR eggNOG; COG2030; Bacteria.
DR HOGENOM; CLU_040078_1_1_11; -.
DR OrthoDB; 5522043at2; -.
DR Proteomes; UP000008190; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd03448; HDE_HSD; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR039569; MaoC-like_dehydrat_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR PANTHER; PTHR13078:SF56; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2; 1.
DR PANTHER; PTHR13078; PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED; 1.
DR Pfam; PF13452; MaoC_dehydrat_N; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008190}.
FT DOMAIN 38..137
FT /note="N-terminal of MaoC-like dehydratase"
FT /evidence="ECO:0000259|Pfam:PF13452"
FT DOMAIN 163..264
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT REGION 148..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 30945 MW; B856305BAB753BD9 CRC64;
MPIDPKIALG AELPSREFAW TASDVQLYQL GLGAGARWTD PAELRYLDDR TPQVLPTFAT
VAQTLHETEP PKVSFPGIDI DLAKVVHGHQ EIEVHRPIPA AGKATSTGRI SEIWDKGSAA
VVVQEHTITG SDGAPLWTAR SSIFAKGEGG FGGERGPSTK SELPDRAPDF DVTTPTLPQQ
ALLYRMLGDR NPLHSDPEFA RAAGFPNPIL HGLCTYGIVC KTATDTVLDS DASRVTGFRA
RFAGVLYPGE TIRTRIWRGE GELIIGASVV ERDNAPVLAD VRLTFQG
//
