ID   H6RLL1_BLASD            Unreviewed;       553 AA.
AC   H6RLL1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=DNA polymerase I family protein with 3'-5'-exonuclease and polymerase domains {ECO:0000313|EMBL:CCG03737.1};
GN   OrderedLocusNames=BLASA_2866 {ECO:0000313|EMBL:CCG03737.1};
OS   Blastococcus saxobsidens (strain DD2).
OC   Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC   Geodermatophilaceae; Blastococcus.
OX   NCBI_TaxID=1146883 {ECO:0000313|EMBL:CCG03737.1, ECO:0000313|Proteomes:UP000007517};
RN   [1] {ECO:0000313|EMBL:CCG03737.1, ECO:0000313|Proteomes:UP000007517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DD2 {ECO:0000313|EMBL:CCG03737.1,
RC   ECO:0000313|Proteomes:UP000007517};
RX   PubMed=22535935; DOI=10.1128/JB.00320-12;
RA   Chouaia B., Crotti E., Brusetti L., Daffonchio D., Essoussi I., Nouioui I.,
RA   Sbissi I., Ghodhbane-Gtari F., Gtari M., Vacherie B., Barbe V., Medigue C.,
RA   Gury J., Pujic P., Normand P.;
RT   "Genome Sequence of Blastococcus saxobsidens DD2, a Stone-Inhabiting
RT   Bacterium.";
RL   J. Bacteriol. 194:2752-2753(2012).
RN   [2] {ECO:0000313|Proteomes:UP000007517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DD2 {ECO:0000313|Proteomes:UP000007517};
RA   Genoscope.;
RT   "Complete genome sequence of Blastococcus saxobsidens strain DD2.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
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DR   EMBL; FO117623; CCG03737.1; -; Genomic_DNA.
DR   RefSeq; WP_014376620.1; NC_016943.1.
DR   AlphaFoldDB; H6RLL1; -.
DR   STRING; 1146883.BLASA_2866; -.
DR   KEGG; bsd:BLASA_2866; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_035229_0_0_11; -.
DR   OrthoDB; 4414061at2; -.
DR   Proteomes; UP000007517; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   CDD; cd06444; DNA_pol_A; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000313|EMBL:CCG03737.1};
KW   Hydrolase {ECO:0000313|EMBL:CCG03737.1};
KW   Nuclease {ECO:0000313|EMBL:CCG03737.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007517}.
FT   DOMAIN          304..512
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   553 AA;  59626 MW;  53F39C34C336885C CRC64;
     MNRVVLRRRE AVVEAHDLAD GGAPAGVARF AAEELPAFVG DREAAVPVRW VWDDTTRWYP
     ALLAAGVRIE RCTDLRLAHA ILRRSPFADQ ALLAADETAA WDELQPVPVA EPALFPPTDP
     ADRLDPVAEH ARQQAALAAS PRRQGLELLL AAESSGALVA AEMTHTGMPW RADVHEQLLT
     ELLGPRPVAG GRPAGLEWLL RQIREAFAAP GLNPDSPAEL LRTLQHAGLP VGDTRSWTLE
     QVDHPGIPPL LEYKKLSRLL TANGWSWLDS WVRQGRFRAT FLPGGVVTGR WASNGGGALS
     VPTQIRPAAV ADEGWCLVVA DVAQLEPRVL AGMSADTAMA EAARAKDLYQ GMVDAGVVPG
     RAEAKVGILG AMYGGTRGES GRMMPRLARR YPRAIGLVEE AARAGERGEV VHTLLGRGSP
     LPTGAWAQRE AELGEPAESA GPRDERDRAR RAWGRFTRNF VVQGTGAEWA LCWLADLRNR
     LWRLGGTGPL HQRPHLAFFL HDEVVVHAPA DLAGAVVEEV RAAAGTAGRL LFGTFPVDFP
     LDVAVVRSWA DAG
//