ID H6SN45_PARPM Unreviewed; 969 AA.
AC H6SN45;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:CCG06921.1};
GN ORFNames=RSPPHO_00295 {ECO:0000313|EMBL:CCG06921.1};
OS Pararhodospirillum photometricum DSM 122.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Pararhodospirillum.
OX NCBI_TaxID=1150469 {ECO:0000313|EMBL:CCG06921.1, ECO:0000313|Proteomes:UP000033220};
RN [1] {ECO:0000313|EMBL:CCG06921.1, ECO:0000313|Proteomes:UP000033220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM122 {ECO:0000313|Proteomes:UP000033220};
RA Duquesne K., Sturgis J.;
RT "Shotgun genome sequence of Phaeospirillum photometricum DSM 122.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; HE663493; CCG06921.1; -; Genomic_DNA.
DR AlphaFoldDB; H6SN45; -.
DR STRING; 1150469.RSPPHO_00295; -.
DR KEGG; rpm:RSPPHO_00295; -.
DR PATRIC; fig|1150469.3.peg.352; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_5; -.
DR Proteomes; UP000033220; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000033220}.
FT DOMAIN 791..807
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 717..724
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 969 AA; 103484 MW; 613A97581C61142A CRC64;
MGKREGWGGG PPQTPRSGGP FASRNAPGSE GSGEARLPSL LFSSCPLRRH GLFSRGQDCS
PSHQDQAMTS APEPETAEIG DVTPMMGQYL SLKAQNPDGL LFYRMGDFYE MFFDDAVAAS
RTLDIALTKR GKHQGADIPM CGVPVHSHES YLARLIRAGH KVVICEQIED PAEARRQRGA
KAVVARAVVR TVTPGTLTED TLLDARRPNY LAALVRQRET LGLAWVDVST GALGAQALDV
ATLGPALARL APGELILPDT LSADPAFAEA LVSVKPVVSP LPASRFDSEN ARKRLHEVFA
VGALDAFGDF GRAEIAALGA VIDYVTLTQA GRLPRLSPPR RLDESAVMAI DPATRRNLEL
FETLTGGRKG SLLATLDRTV TGPGARLLAE RLAAPLTDPE VLNQRLDGVA LFVGATEART
ELRGLLTGCP DIARALSRLS LGRGGPRDLA AVRDGLARVP ALRLGIGALG GGLHALPSDV
SSALAALGQH DALVDLLGRA LADDLPVLAR DGGFIHPGFH AGLDEARALR DESRRLIAAL
QARYVEETGI NTLKIKHNNV LGYFIEVPAG RADRLMGARG AEGQTNPFMH RQTLASQVRF
TTVDLADLED RIRGAAERAL ALEQDLFAEL RDAVLAEAEG IAAAADGLAQ LDVLLALAEL
AETERYCRPV LDRSLAFSLV NARHPVVEAA LKASGEGAFV GNACDLGPGQ RLWLLTGPNM
AGKSTFLRQN ALIVLMAQMG SFVPADQAHL GVVDRLFSRV GAADDLARGR STFMVEMVET
AAILHQATER SLVILDEIGR GTATYDGLSI AWATVESLHD TTRCRALFAT HYHELTVLAK
RLDQLSCHTL RVREWKGEVV FLHEVGPGAA DRSYGIHVAR LAGLPDAVLA RAEEVLATLE
RGDTTPSPAR LVEDLPLFAA ARPRSVPASA PPPPVPPSPV EDALRSLSPD DLSPREALDT
LYRLRALLR
//