ID H7BX90_MOUSE Unreviewed; 1060 AA.
AC H7BX90;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Glutamate receptor interacting protein 1 {ECO:0000313|Ensembl:ENSMUSP00000100897.3};
GN Name=Grip1 {ECO:0000313|Ensembl:ENSMUSP00000100897.3,
GN ECO:0000313|MGI:MGI:1921303};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000100897.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000100897.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100897.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000100897.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000100897.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001264223.1; NM_001277294.1.
DR AlphaFoldDB; H7BX90; -.
DR SMR; H7BX90; -.
DR MaxQB; H7BX90; -.
DR ProteomicsDB; 326518; -.
DR Antibodypedia; 8598; 272 antibodies from 36 providers.
DR DNASU; 74053; -.
DR Ensembl; ENSMUST00000105262.9; ENSMUSP00000100897.3; ENSMUSG00000034813.20.
DR GeneID; 74053; -.
DR UCSC; uc007hem.2; mouse.
DR AGR; MGI:1921303; -.
DR CTD; 23426; -.
DR MGI; MGI:1921303; Grip1.
DR VEuPathDB; HostDB:ENSMUSG00000034813; -.
DR GeneTree; ENSGT00940000158692; -.
DR OrthoDB; 4199121at2759; -.
DR BioGRID-ORCS; 74053; 1 hit in 77 CRISPR screens.
DR ChiTaRS; Grip1; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000034813; Expressed in rostral migratory stream and 192 other cell types or tissues.
DR ExpressionAtlas; H7BX90; baseline and differential.
DR CDD; cd00992; PDZ_signaling; 7.
DR Gene3D; 2.30.42.10; -; 7.
DR InterPro; IPR043545; GRIP1/2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR46227:SF3; GLUTAMATE RECEPTOR-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR46227; GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 7.
DR SUPFAM; SSF50156; PDZ domain-like; 7.
DR PROSITE; PS50106; PDZ; 7.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:H7BX90,
KW ECO:0007829|PeptideAtlas:H7BX90};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 53..136
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 150..238
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 252..336
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 419..494
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 520..605
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 620..702
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 936..1018
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 700..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 114265 MW; 456ECC774B5D311D CRC64;
MIAVSFKCRC QILRRLTKDE SPYTKSASQT KPPDGALAVR RQSIPEEFKG STVVELMKKE
GTTLGLTVSG GIDKDGKPRV SNLRQGGIAA RSDQLDVGDY IKAVNGINLA KFRHDEIISL
LKNVGERVVL EVEYELPPVS VQGSSVMFRT VEVTLHKEGN TFGFVIRGGA HDDRNKSRPV
VITCVRPGGP ADREGTIKPG DRLLSVDGIR LLGTTHAEAM SILKQCGQEA TLLIEYDVSV
MDSVATASGP LLVEVAKTPG ASLGVALTTS VCCNKQVIVI DKIKSASIAD RCGALHVGDH
ILSIDGTSME YCTLAEATQF LANTTDQVKL EILPHHQTRL ALKGPDHAAM VPSSSPTSMS
AYSLSSLNMG TLPRSLYSTS PRGTMMRRRL KKKDFKSSLS LASSTVGLAG QVVHTETTEV
VLTADPVTGF GIQLQGSVFA TETLSSPPLI SYIEADSPAE RCGVLQIGDR VMAINGIPTE
DSTFEEANQL LRDSSITSKV TLEIEFDVAE SVIPSSGTFH VKLPKKHSVE LGITISSPSS
RKPGDPLVIS DIKKGSVAHR TGTLELGDKL LAIDNIRLDN CSMEDAVQIL QQCEDLVKLK
IRKDEDNSDE QESSGAIIYT VELKRYGGPL GITISGTEEP FDPIIISSLT KGGLAERTGA
IHIGDRILAI NSSSLKGKPL SEAIHLLQMA GETVTLKIKK QTDAQSASSP KKFPIPGHSG
DLGDGEEDPS PIQKPGKLSD AYPSTVPSVD SAVDSWDGSG IDASYGSQGS TFQTSGYNYN
TYDWRSPKQR TSLSPVPKPR SQTYPDVGLS NEDWDRSTAS GFVGASDSAD AEQEENFWSQ
ALEDLETCGQ SGILRELEAT IMSGSTMSLN HEAPMARSQL GRQASFQERS SSRPHYSQTT
RSNTLPSDVG RKSVTLRKMK QEIKEIMSPT PVELHKVTLY KDSGMEDFGF SVADGLLEKG
VYVKNIRPAG PGDVGGLKPY DRLLQVNHVR TRDFDCCLVV PLIAESGNKL DLVISRNPLA
SQKSIEQPAL PSDWSEQNSA FFQQPSHGGN LETREPTNTL
//
