ID H7C004_HUMAN Unreviewed; 253 AA.
AC H7C004;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000392381.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000392381.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000392381.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Protease inhibitor that may play a role in the regulation of
CC protease activities during hematopoiesis and apoptosis induced by TNF.
CC May regulate protease activities in the cytoplasm and in the nucleus.
CC {ECO:0000256|ARBA:ARBA00037163}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000256|ARBA:ARBA00006426}.
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DR EMBL; AC072051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C004; -.
DR MaxQB; H7C004; -.
DR PeptideAtlas; H7C004; -.
DR ProteomicsDB; 44133; -.
DR Antibodypedia; 34913; 140 antibodies from 25 providers.
DR Ensembl; ENST00000418725.1; ENSP00000392381.1; ENSG00000289724.1.
DR UCSC; uc060pwm.1; human.
DR GeneCards; ENSG00000289724; -.
DR VEuPathDB; HostDB:ENSG00000242550; -.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000242550; Expressed in bone marrow and 63 other cell types or tissues.
DR ExpressionAtlas; H7C004; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 1.10.287.580; Helix hairpin bin; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF175; SERPIN B10; 1.
DR Pfam; PF00079; Serpin; 2.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..250
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000392381.1"
FT NON_TER 253
FT /evidence="ECO:0000313|Ensembl:ENSP00000392381.1"
SQ SEQUENCE 253 AA; 28575 MW; 7FCED84DD208B691 CRC64;
XSVNKLFGEK SASFREEYIR LCQKYYSSEP QAVDFLECAE EARKKINSWV KTQTKGKIPN
LLPEGSVDGD TRMVLVNAVY FKGKWKTPFE KKLNGLYPFR VNSAQRTPVQ MMYLREKLNI
GYIEDLKAQI LELPYAGDVS MFLLLPDEIA DVSTGLELLE SEITYDKLNK WTSKDKMAED
EVEVSSMDSL ATSINQFALE LSKKLAESAQ GKNIFFSSWS ISTSLTIVYL GAKGTTAAQM
AQVLQFNRDQ GVK
//
