ID H7C0T2_HUMAN Unreviewed; 587 AA.
AC H7C0T2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=ITPRIP like 1 {ECO:0000313|Ensembl:ENSP00000396552.1};
DE Flags: Fragment;
GN Name=ITPRIPL1 {ECO:0000313|Ensembl:ENSP00000396552.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000396552.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000396552.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000396552.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ITPRIP family.
CC {ECO:0000256|ARBA:ARBA00005554}.
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DR EMBL; AC021188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C0T2; -.
DR PeptideAtlas; H7C0T2; -.
DR ProteomicsDB; 44406; -.
DR Antibodypedia; 3069; 111 antibodies from 19 providers.
DR Ensembl; ENST00000420728.1; ENSP00000396552.1; ENSG00000198885.10.
DR UCSC; uc061lvn.1; human.
DR HGNC; HGNC:29371; ITPRIPL1.
DR VEuPathDB; HostDB:ENSG00000198885; -.
DR GeneTree; ENSGT01050000244827; -.
DR PhylomeDB; H7C0T2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000198885; Expressed in sperm and 104 other cell types or tissues.
DR ExpressionAtlas; H7C0T2; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.1410.40; -; 1.
DR InterPro; IPR026250; ITPRIP-like.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF40; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN-LIKE 1; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Proteomics identification {ECO:0007829|EPD:H7C0T2,
KW ECO:0007829|PeptideAtlas:H7C0T2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 450..527
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000396552.1"
SQ SEQUENCE 587 AA; 66803 MW; 7D3572BB66C34B9E CRC64;
XRKGVTQAGS GLSGYKREPL GSAGHIWCPW LTEESDAEAS MAVISLLFLA VMYVVHHPLM
VSDRMDLDTL ARSRQLEKRM SEEMRLLEME FEERKRAAEQ RQKAENFWTG DTSSDQLVLG
KKDMGWPFQA DGQEGPLGWM LGNLWNTGLF CLFLVFELLR QNMQHEPAFD SSSEEEEEEV
RVVPVTSYNW LTDFPSQEAL DSFYKHYVQN AIRDLPCTCE FVESFVDDLI EACRVLSRQE
AHPQLEDCLG IGAAFEKWGT LHETQKFDIL VPIVPPQGTM FVLEMRDPAL GRRCGCVLVE
SECVCKREKL LGDVLCLVHH HRDPSAVLGK CSSSIKAALC TGFHLDVCKT VQWFRNMMGN
AWALVAHKYD FKLSLPPSTT SCKLRLDYRS GRFLSIHLVL GVQREDTLVY LVSQAPDQEQ
LTSVDWPESF VACEHLFLKL VGRFAPENTC HLKCLQIILS LRQHQSLPHG ASRPILTSYH
FKTALMHLLL RLPLTDWAHN MLSQRLQDIL WFLGRGLQQR SLHHFLIGNN FLPLTIPIPK
TFRNAEPVNL FQHLVLNPKA HSQAVEEFQN LLTQVKTLPH APLAAAP
//
