ID H7C1D7_HUMAN Unreviewed; 128 AA.
AC H7C1D7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=8-oxoguanine DNA glycosylase {ECO:0000313|Ensembl:ENSP00000399810.1};
DE Flags: Fragment;
GN Name=OGG1 {ECO:0000313|Ensembl:ENSP00000399810.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399810.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000399810.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000399810.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC022382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C1D7; -.
DR MaxQB; H7C1D7; -.
DR PeptideAtlas; H7C1D7; -.
DR ProteomicsDB; 44607; -.
DR Antibodypedia; 25518; 542 antibodies from 39 providers.
DR Ensembl; ENST00000426518.5; ENSP00000399810.1; ENSG00000114026.22.
DR UCSC; uc062glx.1; human.
DR HGNC; HGNC:8125; OGG1.
DR VEuPathDB; HostDB:ENSG00000114026; -.
DR GeneTree; ENSGT00640000091554; -.
DR HOGENOM; CLU_1975529_0_0_1; -.
DR ChiTaRS; OGG1; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000114026; Expressed in cortical plate and 202 other cell types or tissues.
DR ExpressionAtlas; H7C1D7; baseline and differential.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR012904; OGG_N.
DR PANTHER; PTHR10242; 8-OXOGUANINE DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR10242:SF2; N-GLYCOSYLASE_DNA LYASE; 1.
DR Pfam; PF07934; OGG_N; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF55945; TATA-box binding protein-like; 1.
PE 1: Evidence at protein level;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Proteomics identification {ECO:0007829|EPD:H7C1D7,
KW ECO:0007829|PeptideAtlas:H7C1D7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 4..51
FT /note="8-oxoguanine DNA glycosylase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07934"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000399810.1"
SQ SEQUENCE 128 AA; 14428 MW; 6F8239A69048BA23 CRC64;
XELEAVRKYF QLDVTLAQLY HHWGSVDSHF QEVAQKFQGV RLLRQDPIEC LFSFICSSNN
NIARITGMVE RLCQAFGPRL IQLDDVTYHG FPSLQALAGV PVPAEGLLTS ASAFQSPLRS
RQPEADRR
//
