ID H7C1I7_HUMAN Unreviewed; 1207 AA.
AC H7C1I7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Zinc finger MYM-type containing 4 {ECO:0000313|Ensembl:ENSP00000400506.1};
DE Flags: Fragment;
GN Name=ZMYM4 {ECO:0000313|Ensembl:ENSP00000400506.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400506.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000400506.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0007829|PubMed:17525332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R., Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [3] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4] {ECO:0007829|PubMed:20068231}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6] {ECO:0007829|PubMed:21406692}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8] {ECO:0007829|PubMed:25218447}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [9] {ECO:0007829|PubMed:25114211}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25114211;
RA Impens F., Radoshevich L., Cossart P., Ribet D.;
RT "Mapping of SUMO sites and analysis of SUMOylation changes induced by
RT external stimuli.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:12432-12437(2014).
RN [10] {ECO:0007829|PubMed:25772364}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [11] {ECO:0007829|PubMed:25755297}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25755297; DOI=10.1074/mcp.O114.044792;
RA Xiao Z., Chang J.G., Hendriks I.A., Sigurethsson J.O., Olsen J.V.,
RA Vertegaal A.C.;
RT "System-wide analysis of SUMOylation dynamics in response to replication
RT stress reveals novel small ubiquitin-like modified target proteins and
RT acceptor lysines relevant for genome stability.";
RL Mol. Cell. Proteomics 14:1419-1434(2015).
RN [12] {ECO:0007829|PubMed:28112733}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [13] {ECO:0000313|Ensembl:ENSP00000400506.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL160000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EPD; H7C1I7; -.
DR MassIVE; H7C1I7; -.
DR MaxQB; H7C1I7; -.
DR PeptideAtlas; H7C1I7; -.
DR ProteomicsDB; 44657; -.
DR Antibodypedia; 31536; 133 antibodies from 28 providers.
DR Ensembl; ENST00000457946.1; ENSP00000400506.1; ENSG00000146463.12.
DR UCSC; uc057erv.1; human.
DR HGNC; HGNC:13055; ZMYM4.
DR VEuPathDB; HostDB:ENSG00000146463; -.
DR GeneTree; ENSGT00940000159550; -.
DR HOGENOM; CLU_004099_1_1_1; -.
DR ChiTaRS; ZMYM4; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000146463; Expressed in calcaneal tendon and 210 other cell types or tissues.
DR ExpressionAtlas; H7C1I7; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR021893; DUF3504.
DR InterPro; IPR011017; TRASH_dom.
DR InterPro; IPR010507; Znf_MYM.
DR PANTHER; PTHR45736; ZINC FINGER MYM-TYPE PROTEIN; 1.
DR PANTHER; PTHR45736:SF5; ZINC FINGER MYM-TYPE PROTEIN 4; 1.
DR Pfam; PF12012; DUF3504; 1.
DR Pfam; PF06467; zf-FCS; 6.
DR SMART; SM00746; TRASH; 8.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H7C1I7,
KW ECO:0007829|MaxQB:H7C1I7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 90..126
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 138..178
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 190..228
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 235..274
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 347..383
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 389..424
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 432..470
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT DOMAIN 476..511
FT /note="TRASH"
FT /evidence="ECO:0000259|SMART:SM00746"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..837
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000400506.1"
SQ SEQUENCE 1207 AA; 134420 MW; B5B791257B520A86 CRC64;
XPLDDEYDKA MAPQQGLLDK IKDEPDNAQE YSHGQQQKTQ EGELKISAVF SVSGSPLAPQ
LTTGFQPSLA SSGMNKMLPS VPATAVRVSC SGCKKILQKG QTAYQRKGST QLFCSTLCLT
GYTVPPARPP PPLTKKTCSS CSKDILNPKD VISAQFENTT TSKDFCSQSC LSTYELKKKP
IVTINTNSIS TKCSMCQKNA VIRHEVNYQN VVHKLCSDAC FSKFRSANNL TMNCCENCGG
YCYSGSGQCH MLQIEGQSKK FCSSSCITAY KQNLFNKPTG MNSSVVPLSQ GQVIVSIPTG
STVSAGGGST SAVSPTSISS SAAAGLQRLA AQSQHVGFAR SVVKLKCQHC NRLFATKPEL
LDYKGKMFQF CGKNCSDEYK KINNVMAMCE YCKIEKIVKE TVRFSGADKS FCSEGCKLLY
KHDLAKRWGN HCKMCSYCLQ TSPKLVQNNL GGKVEEFCCE ECMSKYTVLF YQMAKCDACK
RQGKLSESLK WRGEMKHFCN LLCILMFCNQ QSVCDPPSQN NAANISMVQA ASAGPPSLRK
DSTPVIANVV SLASAPAAQP TVNSNSVLQG AVPTVTAKII GDASTQTDAL KLPPSQPPRL
LKNKALLCKP ITQTKATSCK PHTQNKECQT DTPSQPQIIV VPVPVPVFVP IPLHLYTQYA
PVPFGIPVPM PVPMLIPSSM DSEDKVTESI EDIKEKLPTH PFEADLLEMA EMIAEDEEKK
TLSQGESQTS EHELFLDTKI FEKDQGSTYS GDLESEAVST PHSWEEELNH YALKSNAVQE
ADSELKQFSK GETEQDLEAD FPSDSFDPLN KGQGIQARSR TRRRHRDGFP QPRRRGRKKS
IVAVEPRSLI QGAFQGCSVS GMTLKYMYGV NAWKNWVQWK NAKEEQGDLK CGGVEQASSS
PRSDPLGSTQ DHALSQESSE PGCRVRSIKL KEDILSCTFA ELSLGLCQFI QEVRRPNGEK
YDPDSILYLC LGIQQYLFEN GRIDNIFTEP YSRFMIELTK LLKIWEPTIL PNGYMFSRIE
EEHLWECKQL GAYSPIVLLN TLLFFNTKYF QLKNVTEHLK LSFAHVMRRT RTLKYSTKMT
YLRFFPPLQK QESEPDKLTV GKRKRNEDDE VPVGVEMAEN TDNPLRCPVR LYEFYLSKCS
ESVKQRNDVF YLQPERSCVP NSPMWYSTFP IDPGTLDTML TRILMVREVH EELAKAKSED
SDVELSD
//
