ID H7C366_HUMAN Unreviewed; 145 AA.
AC H7C366;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Trifunctional purine biosynthetic protein adenosine-3 {ECO:0000313|Ensembl:ENSP00000409771.1};
DE Flags: Fragment;
GN Name=GART {ECO:0000313|Ensembl:ENSP00000409771.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000409771.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000409771.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RG Chromosome 21 mapping and sequencing consortium;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000409771.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP000302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF457223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C366; -.
DR MaxQB; H7C366; -.
DR PeptideAtlas; H7C366; -.
DR ProteomicsDB; 45225; -.
DR Ensembl; ENST00000366093.6; ENSP00000409771.1; ENSG00000159131.17.
DR UCSC; uc061zqu.1; human.
DR HGNC; HGNC:4163; GART.
DR VEuPathDB; HostDB:ENSG00000159131; -.
DR GeneTree; ENSGT00390000000292; -.
DR HOGENOM; CLU_1800858_0_0_1; -.
DR ChiTaRS; GART; human.
DR Proteomes; UP000005640; Chromosome 21.
DR Bgee; ENSG00000159131; Expressed in ventricular zone and 182 other cell types or tissues.
DR ExpressionAtlas; H7C366; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:InterPro.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR InterPro; IPR004733; PurM_cligase.
DR PANTHER; PTHR10520:SF12; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3; 1.
DR PANTHER; PTHR10520; TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED; 1.
DR Pfam; PF01071; GARS_A; 1.
DR SMART; SM01209; GARS_A; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H7C366,
KW ECO:0007829|MaxQB:H7C366};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 2..123
FT /note="Phosphoribosylglycinamide synthetase ATP-grasp (A)"
FT /evidence="ECO:0000259|Pfam:PF01071"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000409771.1"
SQ SEQUENCE 145 AA; 15126 MW; 44B6953FBBFEDB6A CRC64;
XQWKAFTKPE EACSFILSAD FPALVVKASG LAAGKGVIVA KSKEEACKAV QEIMQEKAFG
AAGETIVIEE LLDGEEVSCL CFTDGKTVAP MPPAQDHKRL LEGDGGPNTG GMGAYCPAPQ
IKNRPGAVAH ACNPSTLGGR GRWIT
//
