ID H7C3W3_HUMAN Unreviewed; 179 AA.
AC H7C3W3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=ALF transcription elongation factor 3 {ECO:0000313|Ensembl:ENSP00000414099.1};
DE Flags: Fragment;
GN Name=AFF3 {ECO:0000313|Ensembl:ENSP00000414099.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000414099.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000414099.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0000313|Ensembl:ENSP00000414099.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC010736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC018690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC073118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC104782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC114793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC133108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C3W3; -.
DR PeptideAtlas; H7C3W3; -.
DR ProteomicsDB; 45467; -.
DR Ensembl; ENST00000430789.1; ENSP00000414099.1; ENSG00000144218.21.
DR UCSC; uc061mhp.1; human.
DR HGNC; HGNC:6473; AFF3.
DR VEuPathDB; HostDB:ENSG00000144218; -.
DR GeneTree; ENSGT00950000182974; -.
DR HOGENOM; CLU_1513935_0_0_1; -.
DR ChiTaRS; AFF3; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000144218; Expressed in cortical plate and 172 other cell types or tissues.
DR ExpressionAtlas; H7C3W3; baseline and differential.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR InterPro; IPR007797; AF4/FMR2.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF16; AF4_FMR2 FAMILY MEMBER 3; 1.
DR Pfam; PF05110; AF-4; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:H7C3W3,
KW ECO:0007829|ProteomicsDB:H7C3W3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REGION 1..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000414099.1"
SQ SEQUENCE 179 AA; 19464 MW; 2406FC92E2B95A3E CRC64;
XASKPSLVQQ KPTAYVRPMD GQDQAPDESP KLKSSSETSV HCTSYRGVPA SKPEPARAKA
KLSKFSIPKQ GEESRSGETN SCVEEIIREM TWLPPLSAIQ APGKVEPTKF PFPNKDSQLV
SSGHNNPKKG DAEPESPDNG TSNTSMLEDD LKLSSDEEEN EQQAAQRTAL RALSDSLSW
//
