ID H7C430_HUMAN Unreviewed; 210 AA.
AC H7C430;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Mitochondrial S-adenosylmethionine carrier protein {ECO:0000256|ARBA:ARBA00039950};
DE AltName: Full=Solute carrier family 25 member 26 {ECO:0000256|ARBA:ARBA00041876};
GN Name=SLC25A26 {ECO:0000313|Ensembl:ENSP00000415304.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415304.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000415304.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000415304.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-
CC homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-
CC L-methionine, the predominant methyl-group donor for macromolecule
CC methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a
CC by-product of methylation reactions. {ECO:0000256|ARBA:ARBA00037638}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) =
CC S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out);
CC Xref=Rhea:RHEA:75479, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789;
CC Evidence={ECO:0000256|ARBA:ARBA00035847};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; AC092034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC145425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC170165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC170801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC235952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEKP01024816; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AUXG01000021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 45532; -.
DR Antibodypedia; 15419; 131 antibodies from 19 providers.
DR Ensembl; ENST00000413054.5; ENSP00000415304.2; ENSG00000144741.19.
DR Ensembl; ENST00000633238; ENSP00000487996; ENSG00000282739.
DR UCSC; uc062lhs.1; human.
DR HGNC; HGNC:20661; SLC25A26.
DR VEuPathDB; HostDB:ENSG00000144741; -.
DR GeneTree; ENSGT00550000074950; -.
DR HOGENOM; CLU_1348554_0_0_1; -.
DR ChiTaRS; SLC25A26; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000144741; Expressed in gastrocnemius and 99 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45667; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR PANTHER; PTHR45667:SF9; S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN; 1.
DR Pfam; PF00153; Mito_carr; 2.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Proteomics identification {ECO:0007829|EPD:H7C430,
KW ECO:0007829|MaxQB:H7C430};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 2..80
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 210 AA; 22645 MW; B6730E557ACF11CF CRC64;
MKHMLAASAG EVVACLIRVP SEVVKQRAQV SASTRTFQIF SNILYEEGIQ GLYRGYKSTV
LREIPFSLVQ FPLWESLKAL WSWRQDHVVD SWQSAVCGAF AGGFAAAVTT PLDVAKTRIT
LAKAGSSTAD GNVLSVLHGV WRSQGLAGDH IPGIFLQEQS SGLPLQRVGR QLPGLRASQL
AVPPPHPDAE LDHLCDCSFC VPLAVLISAI
//
