ID H7C5E4_HUMAN Unreviewed; 1160 AA.
AC H7C5E4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=5'-3' exoribonuclease 1 {ECO:0000313|Ensembl:ENSP00000419683.2};
DE Flags: Fragment;
GN Name=XRN1 {ECO:0000313|Ensembl:ENSP00000419683.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419683.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000419683.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0007829|PubMed:19690332}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [3] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [4] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [5] {ECO:0000313|Ensembl:ENSP00000419683.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC023508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H7C5E4; -.
DR MaxQB; H7C5E4; -.
DR PeptideAtlas; H7C5E4; -.
DR ProteomicsDB; 45990; -.
DR Antibodypedia; 33491; 124 antibodies from 25 providers.
DR Ensembl; ENST00000498077.6; ENSP00000419683.2; ENSG00000114127.11.
DR UCSC; uc062ood.1; human.
DR HGNC; HGNC:30654; XRN1.
DR VEuPathDB; HostDB:ENSG00000114127; -.
DR GeneTree; ENSGT00670000098080; -.
DR ChiTaRS; XRN1; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000114127; Expressed in epithelial cell of pancreas and 189 other cell types or tissues.
DR ExpressionAtlas; H7C5E4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H7C5E4,
KW ECO:0007829|MaxQB:H7C5E4};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 2..63
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 122..310
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 316..541
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 568..637
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 659..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000419683.2"
SQ SEQUENCE 1160 AA; 130190 MW; 4DFEEB21E75F8D8F CRC64;
XTNEDSPIIE YYPPDFKTDL NGKQQEWEAV VLIPFIDERL LEAMETCNHS LKKEERKRNQ
HSECLMCWYD RDTEFIYPSP WPEKFPAIER CCTRYKIISL DAWRVDINKN KITRIDQKAL
YFCGFPTLKH IRHKFFLKKS GVQVFQQSSR GENMMLEILV DAESDELTVE NVASSVLGKS
VFVNWPHLEE ARVVAVSDGE TKFYLEEPPG TQKLYSGRTA PPSKVVHLGD KEQSNWAKEV
QGISEHYLRR KGIIINETSA VVYAQLLTGR KYQINQNGEV RLEKQWSKQV VPFVYQTIVK
DIRAFDSRFS NIKTLDDLFP LRSMVFMLGT PYYGCTGEVQ DSGDVITEGR IRVIFSIPCE
PNLDALIQNQ HKYSIKYNPG YVLASRLGVS GYLVSRFTGS IFIGRGSRRN PHGDHKANVG
LNLKFNKKNE EVPGYTKKVG SEWMYSSAAE QLLAEYLERA PELFSYIAKN SQEDVFYEDD
IWPGENENGA EKVQEIITWL KGHPVSTLSR SSCDLQILDA AIVEKIEEEV EKCKQRKNNK
KVRVTVKPHL LYRPLEQQHG VIPDRDAEFC LFDRVVNVRE NFSVPVGLRG TIIGIKGANR
EADVLFEVLF DEEFPGGLTI RCSPGRGYRL PTSALVNLSH GSRSETGNQK LTAIVKPQPA
VHQHSSSSSV SSGHLGALNH SPQSLFVPTQ VPTKDDDEFC NIWQSLQGSG KMQYFQPTIQ
EKGAVLPQEI SQVNQHHKSG FNDNSVKYQQ RKHDPHRKFK EECKSPKAEC WSQKMSNKQP
NSGIENFLAS LNISKENEVQ SSHHGEPPSE EHLSPQSFAM KGTRMLKEIL KIDGSNTVDH
KNEIKQIANE IPVSSNRRDE YGLPSQPKQN KKLASYMNKP HSANEYHNVQ SMDNMCWPAP
SQIPPVSTPV TELSRICSLV GMPQPDFSFL RMPQTMTVCQ VKLSNGLLVH GPQCHSENEA
KEKAALFALQ QLGSLGMNFP LPSQVFANYP SAVPPGTIPP AFPPPTANIM PSSSHLFGSM
PWGPSVPVPG KPFHHTLYSG TMPMAGGIPG GVHNQFIPLQ VTKKRVANKK NFENKEAQSS
QATPVQTSQP DSSNIVKVSP RESSSASLKS SPIAQPASSF QVETASQGHS ISHHKSTPIS
SSRRKSRKLA VNFGVSKPSE
//
