ID   H8G7Z1_9PSEU            Unreviewed;       928 AA.
AC   H8G7Z1;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Acyl-CoA synthetase (NDP forming) {ECO:0000313|EMBL:EHY88388.1};
GN   ORFNames=SacazDRAFT_01458 {ECO:0000313|EMBL:EHY88388.1};
OS   Saccharomonospora azurea NA-128.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharomonospora.
OX   NCBI_TaxID=882081 {ECO:0000313|EMBL:EHY88388.1};
RN   [1] {ECO:0000313|EMBL:EHY88388.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA-128 {ECO:0000313|EMBL:EHY88388.1};
RX   PubMed=22768365; DOI=10.4056/sigs.2635833;
RA   Klenk H.P., Held B., Lucas S., Lapidus A., Copeland A., Hammon N.,
RA   Pitluck S., Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G.,
RA   Land M., Ivanova N., Rohde M., Goker M., Detter J.C., Kyrpides N.C.,
RA   Woyke T.;
RT   "Genome sequence of the soil bacterium Saccharomonospora azurea type strain
RT   (NA-128(T)).";
RL   Stand. Genomic Sci. 6:220-229(2012).
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DR   EMBL; CM001466; EHY88388.1; -; Genomic_DNA.
DR   AlphaFoldDB; H8G7Z1; -.
DR   HOGENOM; CLU_007415_3_0_11; -.
DR   Proteomes; UP000004705; Chromosome.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd04301; NAT_SF; 1.
DR   Gene3D; 3.40.630.30; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 2.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR003781; CoA-bd.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032875; Succ_CoA_lig_flav_dom.
DR   InterPro; IPR016102; Succinyl-CoA_synth-like.
DR   PANTHER; PTHR43334; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR   PANTHER; PTHR43334:SF1; ACETATE--COA LIGASE [ADP-FORMING]; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF13549; ATP-grasp_5; 1.
DR   Pfam; PF13380; CoA_binding_2; 1.
DR   Pfam; PF13607; Succ_CoA_lig; 1.
DR   SMART; SM00881; CoA_binding; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52210; Succinyl-CoA synthetase domains; 2.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409}.
FT   DOMAIN          38..192
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000259|PROSITE:PS51186"
FT   DOMAIN          690..727
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
FT   REGION          907..928
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   928 AA;  98939 MW;  759E67B6F6E63199 CRC64;
     MAPMGHAPDG VDGDGGRDPF DYPRRWEADV VLADGRTVHL RPIVPTDADR IVALHARLSE
     RTRYLRYFGA YPRIPARDLR RFTTVDHHDR VAFVALLGDD IVAVGRYERI NESSAEVAFV
     VDDAHQGRGL GSILLEHLAA AASECGLRRF VAEVLAENAA MTRVFRDAGY HVSRAFEEGL
     LHLEFDIDPT EESLAVARAR EQAAEARSVH NLLHPRSVAV IGASTDSTKI GYAVLSNLLA
     ADFAGPVYPV NPEHVSVRGV RAYKSVLEIP DPVDLAVVAV PAHQVESVLD GALEKGVQAL
     VIVSAGFAES GPHGLHAELR LVSDARAHGM RVVGPNALGV LNTDPKVRLN ATLAPRLPRR
     GRTGFFCQSG ALGIAILADA EARGLGLSTF VSAGNRADVS GNDLLQYWET DPYTDVVLLY
     LESFGNPRKF ARLARRLART KPVVAVKSGR HAVRPQLAAT STEIDESSVQ ALFEQAGVVR
     VDTLAQLFDT ALVFANQPLP SGARIGIVGN SSAIALLAAD TAKAQGLSIG IEPVDVGSQA
     PPEKFAAAVG SALASPDVDA LVVVFVPPVA TPGTAYARAL RETVLATPTT PEKPIVSTFL
     AAEGVPDELA VTAEDGTVVF GSIPSYPSPE RAVNALARVV RYAEWRRRPQ GTVVRPEGLE
     VQRAEALVRD LVADRSAEDG SVVVPVDDMV QLLGCYGIDV VSFRVVSGVD DAVAAADELG
     YPVTLKAFDD RLRDRPDFAG VRLDLSTPDS VRLAYRDLRE VSGRDEVYVQ RMAPKGVSCA
     IGLQDDPSFG TLVSFGLSGV VSTLLGDQAF RAVPLTDTDA ETLVREPRTA PLLTGYRGDE
     PADLSALQDL VLRVAALAED HPEVRALSLD PVLASPEGAF VTNARIVLGP PPSRPDSGPR
     RLRQITTVAE EDVVEQDDAA QKADGSTA
//