ID H8GC73_9PSEU Unreviewed; 1979 AA.
AC H8GC73;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:EHY87750.1};
GN ORFNames=SacazDRAFT_00802 {ECO:0000313|EMBL:EHY87750.1};
OS Saccharomonospora azurea NA-128.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=882081 {ECO:0000313|EMBL:EHY87750.1};
RN [1] {ECO:0000313|EMBL:EHY87750.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA-128 {ECO:0000313|EMBL:EHY87750.1};
RX PubMed=22768365; DOI=10.4056/sigs.2635833;
RA Klenk H.P., Held B., Lucas S., Lapidus A., Copeland A., Hammon N.,
RA Pitluck S., Goodwin L.A., Han C., Tapia R., Brambilla E.M., Potter G.,
RA Land M., Ivanova N., Rohde M., Goker M., Detter J.C., Kyrpides N.C.,
RA Woyke T.;
RT "Genome sequence of the soil bacterium Saccharomonospora azurea type strain
RT (NA-128(T)).";
RL Stand. Genomic Sci. 6:220-229(2012).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CM001466; EHY87750.1; -; Genomic_DNA.
DR RefSeq; WP_005438871.1; NZ_CM001466.1.
DR HOGENOM; CLU_000022_2_8_11; -.
DR Proteomes; UP000004705; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1425..1498
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1979 AA; 221867 MW; 18D15680E308F44F CRC64;
MSMHDVLAER RAKLSPERLA LLEKLKGAAT SGTSATSIPR RSGDGRVPLS FHQERIWSLD
HLVPDSPAYN VVLSFRLRGP IRHDLLEQAV QQVVDRHEAL RTTFPSEGGV AWQEIAPHVV
VPLPLVDLSP FPEEEREAEF HRRARQEAEH VFDLARGPLL RVTLYRLDDD AYDFLFNTHH
IVTDGWSINN FVRELLVCYE ALLDGRPAPL PDLPVQYADY TVWERDRMRG AFLDERLAYW
RSRLGDRNPG SELPLDRPRP PVQTFRGGSL HFELATDLAD DLRALSRRHH TTLFVTLVSA
LKVLIHRYTA DDEVVVGTPI ANRHHRDIEN LIGFFVNTLV LDTDLAGDPA VSEVLRRVGE
VAKGAYAHQD VPFELLVNEF RPEQGMSMNP LFQVCFALQT APAEEAGEHS LLGPVQEIRN
GTSKFDLWIS IAEREGVLAG SVEYNADIFE HATIERLVDS YQVLLREFAD APDRPVSELR
ILRPEEEHKI LVEWNRTEHD FGEPGRCCLH ELVERQVERR PDQVAVRFEG TDLTYAELDR
RANQLAHLLR ERGVGRNQPV GVCMERSLEL VVALLGVLKA GGAYVPLDPA YPAERLDFMM
ADAAPRLLLT QPGATRLPSH DADVVELGPD WATLADLPDH RPEAVTDSGG LAYLIYTSGS
TGKPKAAMIA HRAIVNRLLW MHDTYGLTEQ DSVLQKTPFS FDVSVWEFFW PLLAGARLVL
ARPDGHRDPA YLAEVIRAEN VTTMHFVPSM LRVFVEEPDL ERCTTLRQVF ASGEALQYAV
QQRFYERLPR ADLHNLYGPT EAAVDVTHWT CLREGGPVNV PIGRPVANTR IYILDRNLRP
VPVGVPGELH IGGVQVADGY HARPELTAER FVPDPFSDEP HARLYRTGDL ARFLPDGTIE
YRGRTDFQVK VRGFRIEPGE VEAALADHPL IREVAVLARE LPGADGDAED RTRLVAYVVP
HPVDDVADPT EPDDQVSEWE RVFSSTYDDE AGQTPADFNI VGWNSSYTGE PLPEEDMRLW
VDSTVERILA LRPKRVLEIG CGTGLLLARI APECAYYCGT DIAQIGLDHI AERVLPTLPN
GVEVELSRQA AHDFSGPAGQ EFDVIVLNSV VQYFPDVDYL RSVLDEAFAR LSPGGAIFLG
DLRNLTLLET FHSEVEVERA DETTTVEQVR RRVRRRVAQE QELLVAPELF PAFAATRDDV
SGVQVLLKRA GRQNELTRYR YDVVLQSGTP AAGDGEPFVL DGASGAPSAE QVRDVLSRHG
ALRVTNLPNP RVRRALTYRA ALASSDPESP VTTLRETVAV EEGADPEWWW QLADELECRA
DVSWQHEAGD GSYQVLLHRG LDPRTWRWPA ADGPLHRYAN SPSLYRIGRR LSAGAADFLR
DRLPEFMVPA AVVAVPELPT DANGKLDRRA LPLPVLDVDD GGYTSPRTDL EKQLADLWAD
VLGVDVGVTT SFFDVGGDSI RGIRLVNKAN RQGLPITAQD VFQYRTIAEL AEEARSRIEA
GHEAAAVETV ERDERLLREV RQRYASAVDA YPLTGTQENI LYRIRRTREP GGNVVHQRFR
ITAESFDPDA FARAWQAAVD RFPVLRTSFC FDLGDDGEPV QVVHRTATLP VHREDWRALK
PSEQERRLQT YVAARRAEGF DLEQAPQSRV ALFRTGEHTY EYVYLFNLAL QDGWSYPLIM
KTVFETYRAL VDGREFTPEP ATAEYGDFCL TQHHRELSGA ERFWRAELAG ADLPAPALAD
RPADSAAART SPPLLHDGIL VPDPVTARLE TLARQWSVTP FTVLQGVWAV QLAATSGRSD
VVFGSVFSGR GTAKVDVEHG VGQYFSILPV RVHVDPAERL GSWFAQLQQR VRRIGEYEYV
PVRKLHEWHG VDRDEFLFDS YLVNETFPEL SSVFDTFSRS LGAEPVEFLN QTEHPLRVET
ILLDSHLVIN FNSYSDRFRP GVVASWLRTY GELIAAVADD PERTVASLLA EAADGTVQR
//
