ID H8GIY9_METAL Unreviewed; 96 AA.
AC H8GIY9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Periplasmic mercury ion-binding protein {ECO:0000256|RuleBase:RU361212};
GN Name=merP {ECO:0000256|RuleBase:RU361212};
GN ORFNames=Metal_3855 {ECO:0000313|EMBL:EIC31496.1};
OS Methylomicrobium album BG8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomicrobium.
OX NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC31496.1, ECO:0000313|Proteomes:UP000005090};
RN [1] {ECO:0000313|EMBL:EIC31496.1, ECO:0000313|Proteomes:UP000005090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BG8 {ECO:0000313|EMBL:EIC31496.1,
RC ECO:0000313|Proteomes:UP000005090};
RX PubMed=23580712;
RA Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S., Op den Camp H.J.,
RA Vuilleumier S., Bringel F., Dispirito A.A., Murrell J.C., Bruce D.,
RA Cheng J.F., Copeland A., Goodwin L., Hauser L., Lajus A., Land M.L.,
RA Lapidus A., Lucas S., Medigue C., Pitluck S., Woyke T., Zeytun A.,
RA Stein L.Y.;
RT "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT Methylomicrobium album Strain BG8.";
RL Genome Announc. 1:E0017013-E0017013(2013).
CC -!- FUNCTION: Involved in mercury resistance. Acts as a mercury scavenger
CC that specifically binds to a mercuric ion in the periplasm and probably
CC passes it to the cytoplasmic mercuric reductase MerA via the mercuric
CC transport protein MerT. {ECO:0000256|RuleBase:RU361212}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|RuleBase:RU361212}.
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DR EMBL; CM001475; EIC31496.1; -; Genomic_DNA.
DR RefSeq; WP_005374888.1; NZ_CM001475.1.
DR AlphaFoldDB; H8GIY9; -.
DR STRING; 686340.Metal_3855; -.
DR eggNOG; COG2608; Bacteria.
DR HOGENOM; CLU_134973_2_1_6; -.
DR Proteomes; UP000005090; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0045340; F:mercury ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015097; F:mercury ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR011795; MerP.
DR InterPro; IPR001802; MerP/CopZ.
DR NCBIfam; TIGR02052; MerP; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00403; HMA; 1.
DR PRINTS; PR00946; HGSCAVENGER.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 4: Predicted;
KW Mercuric resistance {ECO:0000256|RuleBase:RU361212};
KW Mercury {ECO:0000256|RuleBase:RU361212};
KW Metal-binding {ECO:0000256|RuleBase:RU361212};
KW Periplasm {ECO:0000256|RuleBase:RU361212};
KW Reference proteome {ECO:0000313|Proteomes:UP000005090};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..96
FT /note="Periplasmic mercury ion-binding protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003611675"
FT DOMAIN 24..90
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 96 AA; 10013 MW; C5B28C8C83B1571D CRC64;
MKTRIFLFFL ACVATSGVGL AAPRTVTLDV KNMTCAVCPL TVKKALERVA GVQQVSVSYA
DKTATVQFDD AATSAGQLTE ATKNAGYPSS IQAAPK
//
