UniProt: H8GK76

Database: UniProt
Entry: H8GK76_METAL

LinkDB:  H8GK76_METAL 
Original site:  H8GK76_METAL

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Ontology (5)   
   GO (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (7)   
   Pfam (4)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   H8GK76_METAL            Unreviewed;      1835 AA.
AC   H8GK76;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Glutamate synthase family protein {ECO:0000313|EMBL:EIC29200.1};
GN   ORFNames=Metal_1415 {ECO:0000313|EMBL:EIC29200.1};
OS   Methylomicrobium album BG8.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomicrobium.
OX   NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC29200.1, ECO:0000313|Proteomes:UP000005090};
RN   [1] {ECO:0000313|EMBL:EIC29200.1, ECO:0000313|Proteomes:UP000005090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BG8 {ECO:0000313|EMBL:EIC29200.1,
RC   ECO:0000313|Proteomes:UP000005090};
RX   PubMed=23580712;
RA   Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S., Op den Camp H.J.,
RA   Vuilleumier S., Bringel F., Dispirito A.A., Murrell J.C., Bruce D.,
RA   Cheng J.F., Copeland A., Goodwin L., Hauser L., Lajus A., Land M.L.,
RA   Lapidus A., Lucas S., Medigue C., Pitluck S., Woyke T., Zeytun A.,
RA   Stein L.Y.;
RT   "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT   Methylomicrobium album Strain BG8.";
RL   Genome Announc. 1:E0017013-E0017013(2013).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000256|ARBA:ARBA00001927};
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- SIMILARITY: Belongs to the glutamate synthase family.
CC       {ECO:0000256|ARBA:ARBA00009716}.
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DR   EMBL; CM001475; EIC29200.1; -; Genomic_DNA.
DR   RefSeq; WP_005370893.1; NZ_CM001475.1.
DR   STRING; 686340.Metal_1415; -.
DR   eggNOG; COG0067; Bacteria.
DR   eggNOG; COG0069; Bacteria.
DR   eggNOG; COG0070; Bacteria.
DR   HOGENOM; CLU_000422_8_2_6; -.
DR   Proteomes; UP000005090; Chromosome.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0015930; F:glutamate synthase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00713; GltS; 1.
DR   CDD; cd02808; GltS_FMN; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 2.
DR   Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 1.
DR   Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR002489; Glu_synth_asu_C.
DR   InterPro; IPR036485; Glu_synth_asu_C_sf.
DR   InterPro; IPR006982; Glu_synth_centr_N.
DR   InterPro; IPR002932; Glu_synthdom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR11938:SF133; GLUTAMATE SYNTHASE (NADH); 1.
DR   Pfam; PF00310; GATase_2; 1.
DR   Pfam; PF04898; Glu_syn_central; 1.
DR   Pfam; PF01645; Glu_synthase; 1.
DR   Pfam; PF01493; GXGXG; 1.
DR   SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR   SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   3: Inferred from homology;
KW   3Fe-4S {ECO:0000256|ARBA:ARBA00023291};
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005090}.
FT   DOMAIN          24..410
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000259|PROSITE:PS51278"
SQ   SEQUENCE   1835 AA;  201815 MW;  D3C24893D4804CA3 CRC64;
     MNNNSRMSDQ QPLLYDADLS QDSCGVGFIT HKQSIQTHDI LVKTHEALCT IPHRGGMSSE
     GVGDGAGINI DLSLKFFRKI TGLNDLELGR FGVANFFFPE DHDHYDSVTS ELIERHFREA
     KLPIILWRNV PVDNSVLNQA AVKAQQPIKQ VVFGRPEHLK SASHDEYEKY IQAALLDLEK
     EGFTRPELNG FYPLSMSSRT QVYKGRLNSF EVIPYFKDLY DTDHEVSTLF FHTRFSTNTA
     PATMMAQPFR YMAHNGELNT DKKNRLSENA IARQHNKHIC FPCGQSDSGR LDQTLTRRIN
     EDDLDIVTAV LAMMPPAWEN DTTLSPEVRA MLEYFSLYEE KNDGPAALIF NDGIRVGARL
     DRLGLRPLRS VETKEYLAVM SEAGQIDFPP KEVLTRGRIE AGGMLYFDHS TGEKYNSHQV
     MERLAKEKDY RALLKQRSLH LAELPKVELA ELSNDHEFNF DQRHTAYSLN QESFKFLLDP
     ILQTGAEKVS AMGYGLAPNA LSSAEGGMSR YFSQRFAQVT NPPLDSIRES DGMTLRVALG
     AKPTFSDEYS KQLVIDSPIL QRTQLEQIRR EPQVSTVTLD MLYRPDFDDA KRNEDALEAA
     LLDVCAQVEQ AARNNIGIII LSDVKIGREL AAIPALLMIA AANQHLVRMG LRFNSSLIAE
     TGQAASPHDV ATILGFGASA ICPISVHNRV ITDFVPADHQ KALDKFQKGV EKSLMKTMGK
     FGLCTAESYI GGEFFESNYI DTEEPGLAPY FPNIHSSVGG ARFSDIAASA AGWHQKALSV
     QEEKDIPFLG LFKERQDGAG HSYGNTAVRE YINMTDEPIL YIPQDKSPEA SDTAYTDFGY
     TKRTPEQIDN FGITPAYRSF TKNLYLERES RPAALRDIMD FPADVTQAET AQDFDRILGK
     QNLRGNINYL IRGLDVSKTG ENAFAVKLTS NTSTSKARLE QLAEHFKTRF AGTAFTAAIE
     SDALTLKLED ADSLFANYLN RIRAAREPIA LAEVQPAHEI TPTLASGAMS HGALLAEAHE
     TVAQGFNIVG SLSNCGEGGE HSSRFNTLKS CNIKQFASGR FGVWAGYLAD PNLREIEIKI
     AQGAKPGEGG QLPAPKVTVE IAALRGGTPK VELVSPPPHH DTYSIEDLGQ LIHDAKAARV
     KVGVKLVSSE GIGTIAVGVA KAGADVINVA GNTGGTGAAA VTSLKNSGRS PEIGIAEVHQ
     ALSVNGLRDK VILRCSGAHQ SGLDVVKSAI LGADSFEFGT TALMMLRCVM AKNCNVKCPA
     GLTTVHEEFK GDARVLAQYL MNLAHEVREI LAVLGYKSLA EIRGQTGLLH LIEHPSLIGQ
     VDLRKMLAYV DVVKIANPVY LEANFAIDDK IIEKVKAELI EKGQPQVVIE GSEFKLNNRH
     KTIGGQTAID IERMLAYELS EQQIAKAKPI YLNHGKGHRA EGRRYLASET IVIRTTGSAG
     QSYAAFLNDG MRMEHLGTCN DGVGKSMCGG LLIVESPGGG VKTPGNNVLI GNFALFGATG
     GKAFINGEAG DRFAVRNSGA MAVVEGVGDF GCEYMTNGAV LNIGGFGKGF CNGMSGGNAY
     QYDPDNRLEN LYDKSSVELR RLSEDSDVAR AHEQFVISML EQHADYANSS KAKNLLNNWT
     NEREHFKFAL PLWLNKTQSA VFLQKAMDRK EMIEELSVEL ARRQIEQVRE AYRTASPLFG
     GAIPAYGSTD TDLTFKLVNS FMVLEKAQQV AQEMLKHLPE AQRTPARIEQ AARKLIVERP
     RKLQDTLVKT TREAYSNYTD EQLSWLLADK RLNDYKTALI NRSVQSIYSI GSTAWIIEQD
     QVNKAALAGI PSIEQYLASL AGLSIVQGML NEQAA
//

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