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Database: UniProt
Entry: H8GLG9_METAL
LinkDB: H8GLG9_METAL
Original site: H8GLG9_METAL 
ID   H8GLG9_METAL            Unreviewed;       447 AA.
AC   H8GLG9;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   28-MAR-2018, entry version 34.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=Metal_1551 {ECO:0000313|EMBL:EIC29334.1};
OS   Methylomicrobium album BG8.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylomicrobium.
OX   NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC29334.1, ECO:0000313|Proteomes:UP000005090};
RN   [1] {ECO:0000313|EMBL:EIC29334.1, ECO:0000313|Proteomes:UP000005090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BG8 {ECO:0000313|EMBL:EIC29334.1,
RC   ECO:0000313|Proteomes:UP000005090};
RX   PubMed=23580712;
RA   Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S.,
RA   Op den Camp H.J., Vuilleumier S., Bringel F., Dispirito A.A.,
RA   Murrell J.C., Bruce D., Cheng J.F., Copeland A., Goodwin L.,
RA   Hauser L., Lajus A., Land M.L., Lapidus A., Lucas S., Medigue C.,
RA   Pitluck S., Woyke T., Zeytun A., Stein L.Y.;
RT   "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT   Methylomicrobium album Strain BG8.";
RL   Genome Announc. 1:E0017013-E0017013(2013).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|SAAS:SAAS00984457}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
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DR   EMBL; CM001475; EIC29334.1; -; Genomic_DNA.
DR   RefSeq; WP_005371114.1; NZ_CM001475.1.
DR   EnsemblBacteria; EIC29334; EIC29334; Metal_1551.
DR   OrthoDB; POG091H02EK; -.
DR   Proteomes; UP000005090; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005090};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005090}.
FT   DOMAIN       11    103       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      127    441       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
SQ   SEQUENCE   447 AA;  49590 MW;  DBAC6DF8AEAA4EFC CRC64;
     MSAITLQPRI YTVSELNREA ALALGEHFLM VWVEGEISNL SAPSSGHLYF SLKDAGAQVR
     CALFKNQQRG LRCKPANGMQ VIVRAEVSLY EPRGDYQLII ERLEAAGDGA LRRAFEALRW
     KLSAEGLFDP SRKKPLPSLP RAIGIVTSPT GAALRDILSV LRRRFPAIPV IVYPASVQGA
     NAKLEVAAAI DTANRRADCE VLIVARGGGS LEDLQAFNEE IVARAIAASS IPVISGIGHE
     TDVTIADFAA DLRAATPTAA AEHATPDRQQ WLNGFVQSEK RLEQLLQRKL TGAHQRLAWL
     DKRLKQQHPG QKLRRNAQRL DELALRLTQG MQRKQQQHLH QLAAANAKLW RFNPAARIRS
     QQQRQQYLVQ RLQLAMQNKL EQNRLKLANT RQTLHAVSPL ATLNRGYALV TEAESGSLVR
     SARQLAVGDR IRIRVADGQF VSEIVDR
//
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