ID H8GLM0_METAL Unreviewed; 651 AA.
AC H8GLM0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:EIC30547.1};
GN ORFNames=Metal_2860 {ECO:0000313|EMBL:EIC30547.1};
OS Methylomicrobium album BG8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Methylococcales;
OC Methylococcaceae; Methylomicrobium.
OX NCBI_TaxID=686340 {ECO:0000313|EMBL:EIC30547.1, ECO:0000313|Proteomes:UP000005090};
RN [1] {ECO:0000313|EMBL:EIC30547.1, ECO:0000313|Proteomes:UP000005090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BG8 {ECO:0000313|EMBL:EIC30547.1,
RC ECO:0000313|Proteomes:UP000005090};
RX PubMed=23580712;
RA Kits K.D., Kalyuzhnaya M.G., Klotz M.G., Jetten M.S., Op den Camp H.J.,
RA Vuilleumier S., Bringel F., Dispirito A.A., Murrell J.C., Bruce D.,
RA Cheng J.F., Copeland A., Goodwin L., Hauser L., Lajus A., Land M.L.,
RA Lapidus A., Lucas S., Medigue C., Pitluck S., Woyke T., Zeytun A.,
RA Stein L.Y.;
RT "Genome Sequence of the Obligate Gammaproteobacterial Methanotroph
RT Methylomicrobium album Strain BG8.";
RL Genome Announc. 1:E0017013-E0017013(2013).
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
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DR EMBL; CM001475; EIC30547.1; -; Genomic_DNA.
DR RefSeq; WP_005373204.1; NZ_CM001475.1.
DR AlphaFoldDB; H8GLM0; -.
DR STRING; 686340.Metal_2860; -.
DR eggNOG; COG1657; Bacteria.
DR HOGENOM; CLU_019345_0_0_6; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000005090; Chromosome.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005090};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 32..318
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 327..646
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 73337 MW; B61DB3E0606F533E CRC64;
MFTDANTQIN TGSAPSSSTP IQSHAYDLDR AIKKAQDSLI KLQDPAGFWV FELEADCTIP
SEYIMMMHFV DDIDVGLQNK IANYLRSRQS EDGSFPLFTG GPGDISGSVK VYYALKMAGD
DIDAPHMKRL REWILSQGGA AKANVFTRIA LATFEQLPWR GVPYIPVEIM LFPKWFPFHL
DKVSYWSRTV MVPLFILCSM QAKAKNPHKV DILELFTVHP DEEKHYFPEG TLLNKIFLGL
DKLGRLTAPL IPKTMHERAI QKALDWFTER LNGEDGLGGI FPAMVNAYES MLLLGMPEDH
PNVVIARQSI DKLLVINEND AYCQPCLSPV WDTGLAALAL QEANRNGNKA SLTKAYDWLK
TKQLKDEPGD WQVAKPDLPG GGWAFQFNNP HYPDVDDTAV VAFAMADSGL PGMEEPVQRA
TRWIEGMQSK NGGYGAFDAD NTYYYLNEIP FADHGALLDP PTADVSARCA MLMAKVAEER
KEYLPTLERT VEYLRREQEA DGSWFGRWGT NYVYGTWSVL LGLEQTGLPK DDPMYTKAAS
WLKSIQREDG GWGEDNFSYH DTGFSGKYRF STAFQTAWAV LGLIAAGETK SPEVKAGIDF
LLRKQQADGF WNDKCFTAPG FPRVFYLKYH GYDKFFPLWA LARYRNELAR P
//
