ID H8KLX2_SOLCM Unreviewed; 1041 AA.
AC H8KLX2;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Solca_3697 {ECO:0000313|EMBL:AFD08700.1};
OS Solitalea canadensis (strain ATCC 29591 / DSM 3403 / NBRC 15130 / NCIMB
OS 12057 / USAM 9D) (Flexibacter canadensis).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Solitalea.
OX NCBI_TaxID=929556 {ECO:0000313|EMBL:AFD08700.1, ECO:0000313|Proteomes:UP000007590};
RN [1] {ECO:0000313|Proteomes:UP000007590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29591 / DSM 3403 / NBRC 15130 / NCIMB 12057 / USAM 9D
RC {ECO:0000313|Proteomes:UP000007590};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Lu M.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Schroeder M., Kopitz M., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Solitalea canadensis DSM 3403.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP003349; AFD08700.1; -; Genomic_DNA.
DR RefSeq; WP_014681923.1; NC_017770.1.
DR AlphaFoldDB; H8KLX2; -.
DR STRING; 929556.Solca_3697; -.
DR REBASE; 46510; Sca3403ORF3697P.
DR KEGG; scn:Solca_3697; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_007039_0_0_10; -.
DR OrthoDB; 32195at2; -.
DR Proteomes; UP000007590; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFD08700.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007590};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFD08700.1}.
FT DOMAIN 304..558
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 1041 AA; 120740 MW; 3DFA7043D0CF516C CRC64;
MTGQDVIDLI GLDRATSISS VDKNLTESKS IVLNQVGEFG VDAVYFNTDE NENSFPAVFL
KKVESFDSKT LEKIADAQKK IWNYKKVLFF YVYSETEIRI YNCSEKPLIV TQNDFNYEKE
LQNIEIKVYK FSDNKQLEEL NRLFSRIAID TGIIWTLEEA QFIRDRINLQ RRVDKYLVAS
LINTAQLLEQ QGLAVNLIHK LILRSLFLLY LEDRGATDEN LYSKIKNGTK SYFEILDDVN
ATKKLFEVLE GHFNGNVFTV GEDEKISVEQ LQLIKKCFIS GNDNIPQIKL FDDWRLFDFS
IIQIELLSEI YENFLFKTDP ELKKRTGTYY TPPSLVEFIL NEKLPTGKDE KNYSIKILDP
SCGSGIFLVE SFKRLVKRYE NQHKEKLTDF VKLKKLLTDN IFGIELHPQA IKVAAFSLYL
ALLDNLSPKT IWQNKNHRLP NLINNPNDKS LSAEGKNLFC RDTILENKEI ENIEFDLVVG
NPPFGTTDLS ESIRNYCSKY GFGKEMVLPF LHKATMFAPN GEIVLIFNTK VLTNTSGTYQ
NFRKWLFNEC CVEKVYNFSV LRNAKQNFGG QLFGDATGPI SIVFYRKGIP QNLSDKIAYY
APKTYIKSNI VEGLNIDFTD LKYLPLEECQ KPDTKIWKVA MWGGIKDWQL VLKLLETEKN
VGAYLRENKI DYSVGLQPLN NSTEKPIVDN EISKLSFIRP EKIERYYTNK SNFSTINALL
KNKETIESYL EYYSVDKVYD LPPINVFRRI TGKNLFSGPM LLTKEGLKNN QLCFSYIDSA
VAYNSTVLGF KTGNKEILKF LSSILNSELA TYFLLLISNS WGVERERIKP NEIYEFPITN
DIELFKDLVK LHDAIEVKIK NALSYIDFNS IEKEINEKVF NLYNIKSGEK QLIKDFVEFS
VDLFLKQEKS KALYPVLLEQ TIEYGKLISD ELNNFLDGQD LFTNATVYCI NRFSPLMMIK
LSFAIEQNTV VISEDFVDEE LKKMDKYLWE ENASNIYFRK KLNYKKENDI YIIRPNQRRF
WSQSMAIEDA SELILEILNE N
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