ID H8KUL1_SOLCM Unreviewed; 647 AA.
AC H8KUL1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN OrderedLocusNames=Solca_2394 {ECO:0000313|EMBL:AFD07435.1};
OS Solitalea canadensis (strain ATCC 29591 / DSM 3403 / NBRC 15130 / NCIMB
OS 12057 / USAM 9D) (Flexibacter canadensis).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Solitalea.
OX NCBI_TaxID=929556 {ECO:0000313|EMBL:AFD07435.1, ECO:0000313|Proteomes:UP000007590};
RN [1] {ECO:0000313|Proteomes:UP000007590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29591 / DSM 3403 / NBRC 15130 / NCIMB 12057 / USAM 9D
RC {ECO:0000313|Proteomes:UP000007590};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Lu M.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Schroeder M., Kopitz M., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "The complete genome of Solitalea canadensis DSM 3403.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003349; AFD07435.1; -; Genomic_DNA.
DR AlphaFoldDB; H8KUL1; -.
DR STRING; 929556.Solca_2394; -.
DR KEGG; scn:Solca_2394; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG2114; Bacteria.
DR HOGENOM; CLU_028267_0_0_10; -.
DR OrthoDB; 9778366at2; -.
DR Proteomes; UP000007590; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF12; ADENYLATE CYCLASE TYPE 3; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000007590};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 74..107
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 114..147
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 195..228
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 232..265
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 460..591
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 647 AA; 73379 MW; 164C04B68DBCBA4E CRC64;
MKFNKIIICA LLISVPYYGI SQTENTKNLA DTVQVNNYLQ QSKERFNDNP AKAISLAIEA
KKLAEKIKFP KGRAYALKNI GIAYYFQGKY VEALDNYTQS LNQFKEIKDN VGIANLYNNI
GVIYYDQGDD AKALENYLQS LKYAELSKDK LRILSALNNV GGVYNIKDAT YDKALHYYLL
ALPLCEELNR TEELGAISVN IGSIYFDKND DTKALHYFNK ALKAYGNSEG SLNAYNAMGK
LYKREKKYDQ ALENHQKALA LAENLNIKIS IIQSLIGMGN VYLDKGDFKT ALYFFNRAKI
PALEIQAKHE IKDIYQVLSK VYAKTNNYEK AFEYQSLYAN IKDTLYNIES DKKLGNLQFD
FDLQKKQGEI NLLTKDKALQ QLALERQKIA KNSLIAVLGL ICIIGLILYR DYRNKIRLNK
LLDQQKVEIE NLLANILPEE VAKELKEKGQ ATPRYYESVS VLFTDFKSFT AIAETLSPQQ
VVAELSECFT MFDTIIERNN LEKIKTIGDS YMCAGGIPTV NSTHPINIMK AAFEILGFMN
EINNRRKLNG ATPWEIRIGI HTGPLVAGVV GKKKYAYDIW GSTVNIASRM ESNGEPGQIN
ISAAHYELIK HEYECEYRGK ILAKNAGEID MYFVKQKVTV RNIEVSA
//
