ID H8MML0_CORCM Unreviewed; 633 AA.
AC H8MML0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:AFE08464.1};
GN Name=cvrA {ECO:0000313|EMBL:AFE08464.1};
GN OrderedLocusNames=COCOR_07393 {ECO:0000313|EMBL:AFE08464.1};
OS Corallococcus coralloides (strain ATCC 25202 / DSM 2259 / NBRC 100086 / M2)
OS (Myxococcus coralloides).
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Corallococcus.
OX NCBI_TaxID=1144275 {ECO:0000313|EMBL:AFE08464.1, ECO:0000313|Proteomes:UP000007587};
RN [1] {ECO:0000313|EMBL:AFE08464.1, ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RX PubMed=22582372; DOI=10.1128/JB.00397-12;
RA Huntley S., Zhang Y., Treuner-Lange A., Kneip S., Sensen C.W.,
RA Sogaard-Andersen L.;
RT "Complete Genome Sequence of the Fruiting Myxobacterium Corallococcus
RT coralloides DSM 2259.";
RL J. Bacteriol. 194:3012-3013(2012).
RN [2] {ECO:0000313|Proteomes:UP000007587}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25202 / DSM 2259 / NBRC 100086 / M2
RC {ECO:0000313|Proteomes:UP000007587};
RA Huntley S., Zhang Y., Treuner-Lange A., Sensen C.W., Sogaard-Andersen L.;
RT "Genome sequence of the fruiting myxobacterium Corallococcus coralloides
RT DSM 2259.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003389; AFE08464.1; -; Genomic_DNA.
DR RefSeq; WP_014400176.1; NC_017030.1.
DR AlphaFoldDB; H8MML0; -.
DR STRING; 1144275.COCOR_07393; -.
DR KEGG; ccx:COCOR_07393; -.
DR eggNOG; COG0025; Bacteria.
DR eggNOG; COG1226; Bacteria.
DR HOGENOM; CLU_005912_10_1_7; -.
DR InParanoid; H8MML0; -.
DR OrthoDB; 9810759at2; -.
DR Proteomes; UP000007587; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007587};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 50..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..494
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 633 AA; 66501 MW; E51E15D646401E64 CRC64;
MASSLANPSL TLGLSLVAGI LAQLVARHLS VPGIVVLLSA GVLLGPEALG LIQPASLGPA
LQTVVGFSVS VILFEGAMSL DVRKLRREAR SIQRLVTLGA AITAVGGTLA ARALMGWDWK
VSALFGTLVM VTGPTVITPL LRRVRVTHRV ATVLEAEGIF VDAVGAIIAV VALDMALHAE
EGPWLLVSAL GSRWGVGLAV GGITGLLITV GLRKASWVPE DMTNVFALAL VLGAFQVSNA
LAPESGVLAA IAAGLVVGNG KVPARREVLA FKEQLTLMLL GMLFILLAAD MRLSQVTALG
WRGLLTVLVL MLMVRPVAVA ASTAGSGLSR NEKAFIAWLG PRGIVAAAVA SLFATRLGDQ
GVQEGQALRA LVFLVIGVTV VVQGLSGGLV AGLLGVRRVV PRGYVLLGAN ALARQVAHAL
QARDQVVLLV DSSDATLKRA QQEGFRVLFG NGLDERTLLR AEPEGRQGFV GLTHNEGVNL
LFAERVRALQ RTARSYTALH RGHVGVSTDT VSATGGHVLF GAERDLDVWV ARCEQGAVSR
ESWRLEAPQV ETLMPPASGN LEEALVPLVL EREAGTVLFD ESTIPVAGDR VDFLVAHGRK
DEAHAWLSAH GWRLVTSDVP IPDTLPPPGP RDR
//
