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Database: UniProt
Entry: H8WGV3_CAEBR
LinkDB: H8WGV3_CAEBR
Original site: H8WGV3_CAEBR 
ID   H8WGV3_CAEBR            Unreviewed;      2912 AA.
AC   H8WGV3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   SubName: Full=Protein CBR-ITR-1, isoform b {ECO:0000313|EMBL:CCG58647.1};
GN   Name=itr-1 {ECO:0000313|WormBase:CBG05938b};
GN   Synonyms=Cbr-itr-1 {ECO:0000313|EMBL:CCG58647.1};
GN   ORFNames=CBG05938 {ECO:0000313|WormBase:CBG05938b}, CBG_05938
GN   {ECO:0000313|EMBL:CCG58647.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CCG58647.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CCG58647.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CCG58647.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
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DR   EMBL; HE600909; CCG58647.1; -; Genomic_DNA.
DR   WormBase; CBG05938b; CBP38351; WBGene00028294; Cbr-itr-1.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2499   2518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2524   2541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2590   2616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2637   2659       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2754   2776       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      199    253       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    386       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      393    459       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      503    564       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN     1872   1932       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1905   1925       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2912 AA;  332770 MW;  7275B7AF76C48E19 CRC64;
     MNSSFGRVRK KVSIISIPEF VPDSHDNENV ATSGGIVGDK TSSSAGGGGT RIEFDFDDFE
     EQIMRKSSMN LPSRKLTIAS SIDHGNNGNL HIGDIISLYT ESSTNQEQRG FLSTLGLVDD
     RCIVELKDGR PESPPKKFRD CLFKVCPVNR YAAQKHLWTE QKRFQTGDSM FDDDLMNKLR
     VAAEKEREEN EAEFQKTLGN IIQYGSMVQL LHVKSNKYIT VQKNSPAKRE RNAMKVYLDR
     AGNEGSWFII EPAYKHYAIG DNVSAGNKIS LIPNAVSTTQ TGHVKSQLHL SGLNLLDHQT
     AAEVNCLNEP TEWQVFMFLL FDENQQNSVK SGDVVRLFHA DQQTFLTLDT IPKTNPPKDV
     VFLRMTNRPS AADATSSRAL WEVQVVQSNA YRGGTAKWNK TYRFKHLASD MYLTVEESQM
     KAKPAMNGRP PLLSTLSQKS KILERTQSPL ASMYSDGPNG GNDTSDASDG PTVSFLSPKK
     SDFPEDDIKL LFELDPSTFM KSNKEVPRRS YVRLLHHKTA SWVHATNANE KQNLHFSNKN
     EKGWVKVICE THRVDKETFA LLPVNPDEVR DLDFANDACK ALRNFINLIK IGSVISKESL
     NSTTQLLIDC ILFVTNSSDH LADPLKITDF SPSRDRQKLL REQEVLHQVF LLLKAPFQPR
     QGSTELGPLL GSPADLSDSR NEIFKTMFQL CYCLLKYSQV SYRKNQEFLA EKFGEIQEQI
     GFDLMAEDTM TAVLHNNPKL LEKYVKAPHV ERFVDLVRNN RQGKFLDYLA DLCVCRGEAN
     KKIQELICTS VLSDKHRDIF MDTKVINGEV EIGWDPNFRK LVDIAEGAKS NHDDVEHLDY
     YRHQLDLLSQ MCQEQQYLAI DPPVERGLMN ISQQLPAELV LQCMSDTRLP YDLRGSFTRL
     MLHLHVVRGS PMSAIRHARL WRSIPESVNV STYESVSVEA YSDGSRMRIG ASIAHKVLAT
     VETYLMGLRD QPTDERHSVN SSKLTYEIVN LAKSLAQFNF YSFNELLQLT KNLLAIINEG
     PVPEQVPSHQ AMVNVIRNMS KSMLRGGNNK ENSKDLAKTP SMSTDDAGRS KEGRALIVKT
     KLIVAEILQF VMDVRRDYRI TMALSWFKNE FPCDEDGSLM HSASINEKMA SELYDAIYHS
     SGHELHLDGK DGQLLLAILL QMTMSDYPPL TSIALKVLFR HFTQYQELLE DLKQVQLLVS
     NDDVENYRQI DRDLFILKNL TEKSELWVHG DRNHSVETKE VEDKEKTTEY DLHMHQLNTP
     RAFESRDSMD AVIAVINEHY SNFKNESLQL LNRLLINDDR NDEAVALQEL SDKAPLIAYP
     LIRQMLVRLK RMCYRDGKPD TMNQQLLKNM RVYEVVLEFI SVPHDKKHDH EMMKLITLSH
     EFLRDFCKAN KENQSRLYKF ISYEKDAKEG MLRVETVEEV GTLVAIFRNN RELASNVPEE
     LIAHIVGLIE HNSRNPIFLE LLQALVCVYD KEIESGQEKV ANEICAASDE VRQLYVDNAS
     FEELEAMMKQ EKESRGRETE SRKPLKYHIE LVRLLAMCTR GKNGNTELKC ASQIPMDHIV
     RVVTSKHCLV EVKTVYLQLL LHCYIDTDAE MKDAYKTEYV DNILNNLLED IRSLRIDRLT
     DAETVALEHY ICHTVTEVLI KFFEAPYSAL QQAKVDVHHH KKTFSEVLLE LTSLERGKLK
     STRSSRNWYR VAECIKRLTK WAEEHISLPA TLVGPQMSAT ATVRQKWQNA ATSAKLIGLN
     KPVITLVVER LNRQNTLNPG HRLYGTSNSM TEHTSANVVT CYHMMIGEFK FYLHPLHAAE
     GSVLVEVLHT PELLFPEGSA LRDQCARGGV VAKLIQHCKT LMQNKQDNLC SRVLQTLCKM
     CDCTKQQLTQ QGRRFYNSSF EKGQQLRHLL LQRYFGHHNH HHPPLDRQQS KIGEVVEAVK
     EKKEETWSQE RDLYAIQCKL NDAGASDLVI DIIIMEPSRE IFLKAIHLAR ALLHEGNDKV
     QHSFYMRMKQ KDIHEPFFKV ILTRIQTAQN RLKSDMMSCS DSKPKPSSTV LTPLIDAGDT
     GFNGTLFEVP QQVRHPSISE MSQLSNDLTH SIPDLTPYQD EDKSADALPP EVALVEPILR
     VLQLLCENHN SLLQNFLRKQ SDRTNHNLVS ETLSFLDTVC GSTKGSLGVF GEIGEHNFSL
     ITQTLATLTE FCQGPCHENQ NTMAMQENGL NIIISLVLNE IKPLADDHME LALEIKSQAS
     KLLLAIMESR HDGENANRVL RNMANMSGGP KQLVHAIKQA YEMTRSNHHM LKSVSRDLLR
     RAEDDSKSKS GPQITVNTIT LPEINVDASG IVSIHTEKSI SSSLDDKFHE DDSPSVDPRE
     VGHNIYILAH QLAIHDGELE IWLDGSDEKK DDLTREALNY YKERTAQIEI VRRDRTLERV
     VFPINEICSF LTKETKDYVY NNTERDNQGS KVTEFFDQWE TMYHEMIWQR KLQDRKWLSW
     CAVRLPLWTR LSFQFAFIVN ALVALYYPFP ESTSSSISFG NLYSWLAVIS AFLLAHFLRH
     EKAYLSKTAL LILSSLCFLL VNSIGVNLTL YFFGMLQLVN KVIHVLAFVS NKGLEDRPLS
     EILGCRNLHY LLVYLTVCIA GFVIHPMIYC ALLFDIIATE ETLQNVIASV TRNYQSIVWT
     GLLALILLYI FSILGFLFFR HDFYLEVDPV EPDSPASISG ALPTDTCPKE GCPGLERTKD
     NDDDDKKVKS CETLWMCILQ TMYLGLRNGG GIGDVLRNPA PWEDMFVWRV AYDMTFFVVL
     IVIVLNLIFG VIIDTFGDLR AEKNEKEQIL KNNCFICGLD RSRFDNRSVT FESHREMEHN
     IWHYLYYIVM LQIKDETEFT GPESYVAQCV KERNLDWFPR MQALSLQDSE LDTDQSEMKQ
     MKDQMMQMMA MMRENQSQWD EVRAFMEQLQ SR
//
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