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Database: UniProt
Entry: H8XP38_FLAIG
LinkDB: H8XP38_FLAIG
Original site: H8XP38_FLAIG 
ID   H8XP38_FLAIG            Unreviewed;       948 AA.
AC   H8XP38;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460,
GN   ECO:0000313|EMBL:CCG52305.1};
GN   OrderedLocusNames=KQS_01560 {ECO:0000313|EMBL:CCG52305.1};
OS   Flavobacterium indicum (strain DSM 17447 / CIP 109464 / GPTSA100-9).
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1094466 {ECO:0000313|EMBL:CCG52305.1, ECO:0000313|Proteomes:UP000007599};
RN   [1] {ECO:0000313|EMBL:CCG52305.1, ECO:0000313|Proteomes:UP000007599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17447 / CIP 109464 / GPTSA100-9
RC   {ECO:0000313|Proteomes:UP000007599};
RX   PubMed=22582381; DOI=10.1128/JB.00420-12;
RA   Barbier P., Houel A., Loux V., Poulain J., Bernardet J.F., Touchon M.,
RA   Duchaud E.;
RT   "Complete Genome Sequence of Flavobacterium indicum GPSTA100-9T, Isolated
RT   from Warm Spring Water.";
RL   J. Bacteriol. 194:3024-3025(2012).
RN   [2] {ECO:0000313|Proteomes:UP000007599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17447 / CIP 109464 / GPTSA100-9
RC   {ECO:0000313|Proteomes:UP000007599};
RA   Barbier P., Houel A., Loux V., Poulain J., Bernardet J.-F., Touchon M.,
RA   Duchaud E.;
RT   "Complete genome sequence of Flavobacterium indicum GPTSA100-9T, isolated
RT   from warm spring water.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
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DR   EMBL; HE774682; CCG52305.1; -; Genomic_DNA.
DR   RefSeq; WP_014387449.1; NC_017025.1.
DR   AlphaFoldDB; H8XP38; -.
DR   STRING; 1094466.KQS_01560; -.
DR   KEGG; fin:KQS_01560; -.
DR   PATRIC; fig|1094466.5.peg.307; -.
DR   eggNOG; COG0258; Bacteria.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_004675_0_0_10; -.
DR   OMA; NRPPMPD; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000007599; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06139; DNA_polA_I_Ecoli_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007599};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          4..265
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          354..535
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   DOMAIN          705..912
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   948 AA;  107728 MW;  A0E7DF458FEAF569 CRC64;
     MSQKRLFLLD AYALIFRGYY AFIKNPRINS KGMDTSAIMG FMNSLMDVIR REKPDHLAVA
     FDKGGSDYRL EMFTEYKANR DETPEAIKIA VPYIQELLRA MHIPIIEEAG YEADDLIGTL
     AKQAEKQGYK VFMVTPDKDF GQLVSENIFM YRPARMGNDI EIWGVDEVKA KFEVEHPLQV
     IDFLGMMGDA VDNIPGLPGV GEKTAKKLLA EFGSMENLLE NTDKLKGALK EKIEANKEKG
     ILSKKLATIL LDCPVTFNET DYELSKPDVE KTDAIFQELE FRQMKAQFDK LFGSGKEYDE
     IDTNGTDTNL ITKKAPIKKA PENQMDLFGF SDDESDEPKG HSFYATLETT NHFYQIVQGE
     IPTRLLIQNL MTQKSVCFDT ETTGIDALNA ELVGMSFSWE KGKAFYVPFP ENQEEAQQLA
     NKFKPFFENE AIEKIGQNMK YDLKVLRNYG LEVKGSLFDT MIAHYLINPD MRHNMDVLAE
     TYLKYSPKSI ETLIGKKGKG QKSMRDVALE DIKEYAAEDA DITLQLKENF QPILEKVGTK
     KLFDEIEIPL VQVLADMEAE GIRLDVDFLK EMSKEMAIEI QLLEQKIYET AGETFNLASP
     KQLGDILFDK LKIGGAKQKK TKTGQYATGE EILSYLANDH EIVRNILEWR QMVKLQSTYI
     DALPNQVDAK TQRVHTDYMQ TVAATGRLSS NNPNLQNIPI RTERGRQIRK AFIARDENYT
     LVSADYSQIE LRIIAALSGE ENMIKAFQNH EDIHKSTAAK VFNVPLEEVT KEQRSHAKTV
     NFGIIYGVSA FGLSNQTNLS RKESAELIEA YYQNYPKLKS FMSHQVDFAR EHGYVETISG
     RRRYLKDINS ANAIVRGGAE RNAVNAPIQG SAADIIKIAM INIHKRLKQE NWQSKMLLQV
     HDELVFDVHN SELEKIQPMI KHEMENAFIM AVPLEVEIGL GKDWLAAH
//
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