ID H8XR86_FLAIG Unreviewed; 590 AA.
AC H8XR86;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Protease IV (Signal peptide peptidase) {ECO:0000313|EMBL:CCG54320.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:CCG54320.1};
GN Name=sppA {ECO:0000313|EMBL:CCG54320.1};
GN OrderedLocusNames=KQS_12060 {ECO:0000313|EMBL:CCG54320.1};
OS Flavobacterium indicum (strain DSM 17447 / CIP 109464 / GPTSA100-9).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1094466 {ECO:0000313|EMBL:CCG54320.1, ECO:0000313|Proteomes:UP000007599};
RN [1] {ECO:0000313|EMBL:CCG54320.1, ECO:0000313|Proteomes:UP000007599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17447 / CIP 109464 / GPTSA100-9
RC {ECO:0000313|Proteomes:UP000007599};
RX PubMed=22582381; DOI=10.1128/JB.00420-12;
RA Barbier P., Houel A., Loux V., Poulain J., Bernardet J.F., Touchon M.,
RA Duchaud E.;
RT "Complete Genome Sequence of Flavobacterium indicum GPSTA100-9T, Isolated
RT from Warm Spring Water.";
RL J. Bacteriol. 194:3024-3025(2012).
RN [2] {ECO:0000313|Proteomes:UP000007599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17447 / CIP 109464 / GPTSA100-9
RC {ECO:0000313|Proteomes:UP000007599};
RA Barbier P., Houel A., Loux V., Poulain J., Bernardet J.-F., Touchon M.,
RA Duchaud E.;
RT "Complete genome sequence of Flavobacterium indicum GPTSA100-9T, isolated
RT from warm spring water.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; HE774682; CCG54320.1; -; Genomic_DNA.
DR RefSeq; WP_014389438.1; NC_017025.1.
DR AlphaFoldDB; H8XR86; -.
DR STRING; 1094466.KQS_12060; -.
DR MEROPS; S49.001; -.
DR KEGG; fin:KQS_12060; -.
DR PATRIC; fig|1094466.5.peg.2356; -.
DR eggNOG; COG0616; Bacteria.
DR HOGENOM; CLU_008856_1_1_10; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000007599; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CCG54320.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:CCG54320.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007599};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..276
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 371..518
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 191
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 387
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 590 AA; 65460 MW; 57A25AB30A7D0BB6 CRC64;
MNFIKNVLAT VVGIFLFCVI SFFILIGIAA VVSGGENEIK IENNSVIELD LSKIVFDYAG
KYKDESPLQA LIAGKTKIGF IDVLNAIKSA KNDDKIKGIS IINNQSLLGL AQSKELREQL
LDFKKSGKFV YAYANYFTQK EYYINSVADQ VYVNPVGEVD FKGLHSELLF FKDFQDKTGI
KFEVIRHGKY KSAVEPFLNQ EMSPENREQM TALLNSVWNT IVTDVAASRK IPVEQLNAIA
ENLSARTPEM ALAQKLVDKV AYEDEYHAAI KSKLKVANDE EYKKISITDY TDKNSINVDD
ITKDDIIAVI YAQGEINGGE GDVDFIGEGS INRSLKEARE DKDVKAIVLR VDSPGGSALT
SELIWREIEL TKKIKPVVVS MGNLAASGGY YISCGANAIF AEPTTITGSI GVFGMLPNMS
ELASKVGVNA EQVNTHKNSG GYSPFEPITE EYKAIALEGV ERTYKTFVTR VATGRKMKFE
AVDAIGQGRV WTGTDALKLG LVDKLGNLDA AIKHAATLGK SKEYRVETYP EYNKNFNEFL
ESLAGAKMYQ SKEAYLKEEI GEENYILIDK IRKMKKRKGI QAIMPYEISF
//
