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Database: UniProt
Entry: H8XTB1_FLAIG
LinkDB: H8XTB1_FLAIG
Original site: H8XTB1_FLAIG 
ID   H8XTB1_FLAIG            Unreviewed;       476 AA.
AC   H8XTB1;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   23-MAY-2018, entry version 44.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCG52708.1};
GN   OrderedLocusNames=KQS_03610 {ECO:0000313|EMBL:CCG52708.1};
OS   Flavobacterium indicum (strain DSM 17447 / CIP 109464 / GPTSA100-9).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1094466 {ECO:0000313|EMBL:CCG52708.1, ECO:0000313|Proteomes:UP000007599};
RN   [1] {ECO:0000313|Proteomes:UP000007599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17447 / CIP 109464 / GPTSA100-9
RC   {ECO:0000313|Proteomes:UP000007599};
RA   Barbier P., Houel A., Loux V., Poulain J., Bernardet J.-F.,
RA   Touchon M., Duchaud E.;
RT   "Complete genome sequence of Flavobacterium indicum GPTSA100-9T,
RT   isolated from warm spring water.";
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; HE774682; CCG52708.1; -; Genomic_DNA.
DR   RefSeq; WP_014387850.1; NC_017025.1.
DR   EnsemblBacteria; CCG52708; CCG52708; KQS_03610.
DR   KEGG; fin:KQS_03610; -.
DR   PATRIC; fig|1094466.5.peg.712; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; FIND1094466:G1HK7-726-MONOMER; -.
DR   Proteomes; UP000007599; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007599};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007599}.
FT   DOMAIN      173    303       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      384    453       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     181    188       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   476 AA;  54472 MW;  A522992D37BF0E1E CRC64;
     MNKAAKSVWT NCLSFIKDNI QDQAFKTWFE PIVAINLTED NALHIQVPSK FFYEWLEEHY
     VTILKTALTK ELGNQAKLVY KIKMENTYGN KLPFTEQIPS SQRSSVKTQE IDVPIVNKNP
     ELKNPFIIPG IRNVKIESQL NSNYSFDNFL EGDSNRLARS AGMAVANKPG GTSFNPLLIF
     GGVGLGKTHL AHAIGVEIKD KFPEKTVLYI SAEIFTQQYI ESVKKNTRND FIHFYQLIDV
     LIIDDVQFLS GKAGTQDVFF HIFNYLHQNG KQVILTSDKA PVDMQDIEQR LLSRFKWGLS
     AELHQPDYET RISILKNILY RDGVEMPDEI VEYVAKHIKS NVRELEGAII SLIAQSSFNK
     REVTIELAKQ VVEKFVKNIK REISIDYIQK VVSDYFQIDT ETLKSKTRKR HIVQARQLAM
     FFAKKFTKAS LANIGNQIGD RDHATVLHAC KTVDNLVTTD KQFRKFVDDI NKKLSV
//
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