ID H8YHW6_MOUSE Unreviewed; 146 AA.
AC H8YHW6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Cholinergic receptor, nicotinic, gamma polypeptide {ECO:0000313|Ensembl:ENSMUSP00000140796.2};
DE SubName: Full=Nicotinic acetylcholine receptor gamma subunit variant {ECO:0000313|EMBL:AEA02367.1};
DE Flags: Fragment;
GN Name=Chrng {ECO:0000313|EMBL:AEA02367.1,
GN ECO:0000313|Ensembl:ENSMUSP00000140796.2, ECO:0000313|MGI:MGI:87895};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AEA02367.1};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000140796.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140796.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|EMBL:AEA02367.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:AEA02367.1};
RA Azim S., Banday A.R., Tabish M.;
RT "Transcript of gamma subunit of nicotinic acetylcholine receptor is widely
RT expressed in different tissue types of adult mouse.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000140796.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000140796.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell
CC membrane {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
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DR EMBL; JF520813; AEA02367.1; -; mRNA.
DR Antibodypedia; 20220; 158 antibodies from 27 providers.
DR Ensembl; ENSMUST00000188796.7; ENSMUSP00000140796.2; ENSMUSG00000026253.15.
DR UCSC; uc033fkf.1; mouse.
DR AGR; MGI:87895; -.
DR MGI; MGI:87895; Chrng.
DR VEuPathDB; HostDB:ENSMUSG00000026253; -.
DR GeneTree; ENSGT00940000160041; -.
DR HOGENOM; CLU_018074_7_2_1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026253; Expressed in lens of camera-type eye and 70 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR PANTHER; PTHR18945:SF60; ACETYLCHOLINE RECEPTOR SUBUNIT GAMMA; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00254; NICOTINICR.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023257};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AEA02367.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..146
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015093758"
FT DOMAIN 26..129
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT NON_TER 146
FT /evidence="ECO:0000313|EMBL:AEA02367.1"
SQ SEQUENCE 146 AA; 17113 MW; B71710D713081A27 CRC64;
MQGGQRPQLL LLLLAVCLGA QSRNQEERLL ADLMRNYDPH LRPAERDSDV VNVSLKLTLT
NLISLNEREE ALTTNVWIEM QWCDYRLRWD PKDYEGLWIL RVPSTMVWRP DIVLENKSQT
YSTSEINLQL SQEDGQAIEW IFIDPE
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