ID   H9G4I5_ANOCA            Unreviewed;       351 AA.
AC   H9G4I5;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Ubiquitin recognition factor in ER associated degradation 1 {ECO:0000313|Ensembl:ENSACAP00000000925.4};
GN   Name=UFD1 {ECO:0000313|Ensembl:ENSACAP00000000925.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000925.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000000925.4}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000925.4};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000000925.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the UFD1 family.
CC       {ECO:0000256|ARBA:ARBA00006043}.
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DR   RefSeq; XP_008115569.1; XM_008117362.2.
DR   AlphaFoldDB; H9G4I5; -.
DR   STRING; 28377.ENSACAP00000000925; -.
DR   Ensembl; ENSACAT00000000953.4; ENSACAP00000000925.4; ENSACAG00000000892.4.
DR   GeneID; 100557046; -.
DR   CTD; 7353; -.
DR   eggNOG; KOG1816; Eukaryota.
DR   GeneTree; ENSGT00390000002408; -.
DR   HOGENOM; CLU_037790_2_0_1; -.
DR   InParanoid; H9G4I5; -.
DR   OrthoDB; 1125766at2759; -.
DR   TreeFam; TF314581; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000000892; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR   GO; GO:0036501; C:UFD1-NPL4 complex; IEA:Ensembl.
DR   GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR   GO; GO:0036435; F:K48-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR   GO; GO:0039536; P:negative regulation of RIG-I signaling pathway; IEA:Ensembl.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR   GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:Ensembl.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 3.10.330.10; -; 1.
DR   Gene3D; 2.40.40.50; Ubiquitin fusion degradation protein UFD1, N-terminal domain; 1.
DR   InterPro; IPR004854; Ufd1-like.
DR   InterPro; IPR042299; Ufd1-like_Nn.
DR   PANTHER; PTHR12555; UBIQUITIN FUSION DEGRADATON PROTEIN 1; 1.
DR   PANTHER; PTHR12555:SF13; UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1; 1.
DR   Pfam; PF03152; UFD1; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..264
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  38895 MW;  6D1E0388866F7198 CRC64;
     MASSEDLPET PPLLLSRRRR HSGTCSSGVS PNTTLQGLAS LRCLPKHSLE REGLSCGGVS
     GGEASDKRRC GGLGRVQKKR SRGGTPVRHV IMPPSALDQL SRLNITYPML FKLTNKNSDR
     MTHCGVLEFV ADEGICYLPH WMMQNLLLEE GGLVQIESVN LQVATYSKFQ PQSPDFLDIT
     NPKAVLENAL RNFACLTTGD VIAINYNEKI YELRVMETKP DKAVSIIECD MNVDFDAPLG
     YKEPERQAQH EEATEGEADP GDYVSDKGFR AFSGSGNRLD GKKKGVEANP FPIKPGDIRR
     GIPNYEFKIG KITFIRNSRP QVKKIEEDDP GQRFIAFSGE GQSLRKKGRK P
//